Hepatoprotective and Antioxidant Activity of Amorphophallus campanulatus Tubers Extract against Paracetamol - Induced Liver Damage in Rats
Surendra Kumar Singh, Nripendra Singh, Ritu Singh
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–6 · Published 10 Dec 2016
10.9734/JAMPS/2016/29419Abstract
The present study was to evaluate the hepatoprotective and antioxidant activity of the methanolic and aqueous extracts of Amorphophallus campanulatus (A. campanulatus) tubers against Paracetamol induced liver damage in rats. The administration of extracts at a dose 300 mg/ kg restored the elevated serum enzyme levels to normal. Silymarin was used as a standard reference, exhibited significant hepatoprotective activity. The biochemical and histopathological results proved that Amorphophallus campanulatus tubers had hepatoprotective potency to liver damage due to paracetamol. The increase in the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) shows that the plant may possess antioxidant property. It was concluded from the results that methanolic extract possessed more potent hepatoprotective and antioxidant activity than aqueous extract.
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