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Research Article Open access CC BY 4.0

Changes in the Pulmonary Functions of Individuals with Sickle Cell Disease: A Scoping Review

Uchenwoke Chigozie Ikenna, Ede Sunday Stephen

Annual Research & Review in Biology · pp. 91–113 · Published 25 Jun 2020

10.9734/arrb/2020/v35i530228

Abstract

Background: Individuals with sickle cell disease (ISCD) are often subject to various changes in crucial health profiles with a consequent need for reduced physical activities, which could be as a result of their declining pulmonary functions. Few studies have systematically attempted to examine the changes in the pulmonary function of ISCD comprehensively. Objective: The purpose of this review is to explore the changes in pulmonary functions of ISCD. Methods: A scoping review comprising 36 studies was conducted to identify and examine the literature related to changes in the pulmonary functions of ISCD, and to compare how they correlate with their health profile. Results: Most common changes cited were demographic factors (26 papers), followed by haematological indices (18 papers) followed by pulmonary complications (16 papers), and anthropometric values (13 papers), with the most common themes overall being age while FEV1, FVC, and FEV1/FVC where the most outcome measures examined. Conclusion: With current advances in medicine, the life expectancy of ISCD is on the increase. We conclude that an evidence-based therapy for pulmonary functions maintenance will be a valid and valuable care for ISCD. Further research must be done, mainly to focus on each health profile holistically.

ISCD sickle cell disease pulmonary functions health profile.

References (42)

  1. 1 Scoping studies: towards a methodological framework [DOI]
  2. 2 Whatever happened to qualitative description? [DOI]
  3. 3 Sickle Cell Disease [DOI]
  4. 4 Improved survival of children and adolescents with sickle cell disease [DOI]
  5. 5 Pulmonary Complications of Sickle Cell Disease [DOI]
  6. 6 Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease [DOI]
  7. 7 Management of Sickle Cell Disease: A Review for Physician Education in Nigeria (Sub-Saharan Africa) [DOI]
  8. 8 Asthma in children with sickle cell disease and its association with acute chest syndrome [DOI]
  9. 9 Pulmonary Complications of Sickle Cell Disease [DOI]
  10. 10 Iron overload is a determinant of morbidity and mortality in adult patients with sickle cell disease [DOI]
  11. 11 Exercise limitation, exercise testing and exercise recommendations in sickle cell anemia [DOI]
  12. 12 Pulmonary function in sickle cell disease with or without acute chest syndrome [DOI]
  13. 13 Longitudinal Decline in Lung Volume in a Population of Children with Sickle Cell Disease [DOI]
  14. 14 Airway Hyperresponsiveness in Children With Sickle Cell Anemia [DOI]
  15. 15 Longitudinal assessment of lung function in children with sickle cell disease [DOI]
  16. 16 Abnormal Pulmonary Function and Associated Risk Factors in Children and Adolescents With Sickle Cell Anemia [DOI]
  17. 17 Pulmonary complications of sickle cell disease in children [DOI]
  18. 18 Airways obstruction and pulmonary capillary blood volume in children with sickle cell disease [DOI]
  19. 19 Balancing exercise risk and benefits: lessons learned from sickle cell trait and sickle cell anemia [DOI]
  20. 20 Lung function in children with sickle cell disease from Central Africa [DOI]
  21. 21 Secondhand Smoke Is an Important Modifiable Risk Factor in Sickle Cell Disease: A Review of the Current Literature and Areas for Future Research [DOI]
  22. 22 Pulmonary function abnormalities in childhood sickle cell disease [DOI]
  23. 23 Exercise tolerance, lung function abnormalities, anemia, and cardiothoracic ratio in sickle cell patients [DOI]
  24. 24 Improved Survival of Children and Adolescents with Sickle Cell Disease. [DOI]
  25. 25 Pilot randomized controlled trial to evaluate the effect of aquatic and land physical therapy on musculoskeletal dysfunction of sickle cell disease patients [DOI]
  26. 26 Heterogeneity of respiratory disease in children and young adults with sickle cell disease [DOI]
  27. 27 Lung Function Abnormalities in Sickle Cell Anaemia [DOI]
  28. 28 Progression and Prognostic Indicators of Bronchial Disease in Children with Sickle Cell Disease [DOI]
  29. 29 Equation to estimate resting energy expenditure in adolescents with sickle cell anemia [DOI]
  30. 30 Respiratory muscle force and lung volume changes in a population of children with sickle cell disease [DOI]
  31. 31 Acute chest syndrome in sickle cell anaemia: higher serum levels of interleukin-8 and highly sensitive C-reactive proteins are associated with impaired lung function [DOI]
  32. 32 Correlates of Pulmonary Function in Children with Sickle Cell Disease and Elevated Fetal Hemoglobin [DOI]
  33. 33 Lung Function Tests in Sickle-Cell Patients in Benin City [DOI]
  34. 34 Pulmonary Function Correlates with Body Composition in Nigerian Children and Young Adults with Sickle Cell Disease [DOI]
  35. 35 Pulmonary function studies in Kuwaiti children with sickle cell disease and elevated Hb F [DOI]
  36. 36 Airway and alveolar nitric oxide production, lung function, and pulmonary blood flow in sickle cell disease [DOI]
  37. 37 Lung function and somatic growth in patients with hemoglobin SC sickle cell disease [DOI]
  38. 38 Dyspnea, pulmonary function and exercise capacity in adult Saudi patients with sickle cell disease [DOI]
  39. 39 Somatic Growth and Lung Function in Sickle Cell Disease [DOI]
  40. 40 Pulmonary function profile of children with sickle cell disease [DOI]
  41. 41 Musculoskeletal complications in sickle cell anemia patients: a ten-year retrospective review of hospital-based records (1991-2000) in two Nigerian hospitals [DOI]
  42. 42 Heart disease: A textbook of cardiovascular medicine [DOI]

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