Clinicopathological Spectrum of Glandular Odontogenic Cyst - Report of Three Cases

Abstract

Glandular odontogenic cyst (GOC) is rare locally aggressive lesion of jaw constituting 0.012% to 1.3% of all odontogenic cysts. It commonly occurs in mandible (70%) than maxilla (30%). It arises from rest of dental lamina. Cysts radiologically appear as unilocular or multilocular radiolucency with a well-defined corticated border which mimics dentigerous cyst and lateral periodontal cyst. Histopathologically intraepithelial microcysts, presence of hobnail cells, epithelial lining is of  variable thickness with sometimes apocrine snouting are  observed. Clinical and radiographic features are nonspecific, and to its similarities with other lesions, it can be misdiagnosed. Treatment modalities of GOC are curettage, enucleation or marsupialization depending on aggressiveness of lesion. In this case series three cases of GOC have been reported of which two are in mandible and one is in maxilla. Diagnosis was confirmed by histopathology and immunohistochemistry (IHC) markers which were strongly positive for CK19 and negative for CK 18.