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Research Article Open access CC BY 4.0

Comparative Analysis of the Hypoglycaemic and Hypolipidemic Effects of Aqueous Extract of some Ethno medicinal Plants in Alloxan Induced Diabetic Rats

Idris Aliyu Kankara, Akos Noel Ibrahim, Haruna Ade

Asian Journal of Research in Biochemistry · pp. 40–48 · Published 9 Nov 2021

10.9734/ajrb/2021/v9i230199

Abstract

Diabetes mellitus is a complex metabolic disorder associated with the development of metabolic complications. This research evaluated the hypoglycemic and hypolipidaemic effects of Moringa oleifera (MO), Treculia africana (TA) and Albizzia chevalieri (AC) plant extracts on diabetes. Albino rats were randomly divided into six (six) main groups; MC, MO, TA, AC, Normal Control (NC) and Diabetic Control (DC) groups. Group MO, TA and AC were further subdivide into three sub groups. Diabetes mellitus was induced by a single dose intraperitoneal injection of alloxan 150 mg/kg body weight. Fasting blood glucose level and lipid profile were assayed using standard methods. Intraperitoneal injection of 150 mg/kg of Alloxan in the albino rats resulted in significant (p<0.05) elevation of serum glucose, total cholesterol (TC), triglyceride (TG), very low density lipoprotein (VLDL-C), and low density lipoprotein (LDL-C). Also, there was significant decrease (p<0.05) in HDL-C and body weight of the albino rats compared with that of the NC group. Oral administration of MO, TA and AC to diabetic albino rats for 21 days significantly (p<0.05) reduced fasting blood glucose level, normalized lipid profile and restore body weight of the albino rats in treated groups compared to diabetic control groups. All the plant extracts studied in this research significantly (p<0.05) increase the regeneration of damaged pancreatic β cells. Treatment with MO (800 mg/kg) confirmed highly significant (p<0.05) effect compared to TA and AC.

Hypoglycaemia hypolipidemia ethnomedicinal plants

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Cited by 4

Hepatocurative Effect of Some Ethnomedicinal Plants on Liver Function Indices in Alloxan- Induced Diabetic Rats

Idris Aliyu Kankara, Akos Noel Ibrahim, Haruna Ade · Asian Journal of Research in Biochemistry · 2023

Phytochemical constituents and alpha-amylase inhibition of Nigerian Globimetula oreophila (Hook.f.) Danser (Loranthaceae) and Solanum erianthum D.Don (Solanaceae) methanol extracts

O. Bamidele, Thomas Abu, O. Ogbole · International Journal of Secondary Metabolite · 2026

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