Efficacy and Tolerability of MlC601 in Patients with Mild to Moderate Alzheimer Disease who were Unable to Tolerate or Failed to Benefit from Treatment with Rivastigmine
Ali Amini Harandi, Farzad Ashrafi, Mojgan Tabatabaei, Askar Ghorbani, Hamidreza Hatamian, Hossein Pakdaman, Manochehr Ilkhani, Koroush Gharagozli, Maziar Shojae, Marjan Asadollahi, Farshid Alaeddini, Seyed Kazem Hosseini
Journal of Advances in Medicine and Medical Research · pp. 341–350 · Published 13 Feb 2013
10.9734/BJMMR/2013/2537Abstract
Aim: To evaluate the efficacy and tolerability of MLC601 in patients with mild to moderate Alzheimer disease (AD). Study Design: This is an open-label pilot study. Place and Duration of Study: It was conducted at three university referral centres in Iran from September 2009 until November 2011. Methodology: One-hundred and twenty four outpatients with mild to moderate AD who had previously failed to tolerate or benefit from treatment with Rivastigmine for 6 months at a dose of 2 to 12 mg per day were switched to a MLC601 regimen of one capsule three times per day for up to 18 months. Outcome measures included adverse events (AEs), withdrawal rate, and changes in the Mini-Mental State Examination (MMSE) and the cognitive subscale of the AD Assessment Scale (ADAS-cog) relative to baseline measurements. Results: Two patients were lost to follow up, and 122 patients completed the 18-month trial. The mean age of the participants was 65.3±6.4 years (range 54-82), and 77 (63.1%) of the participants were female. Improved cognitive function was observed in the first 6 months of the regimen (ADAS-cog=-3.1±10.1; MMSE=1.2±3.0), and the stabilisation of cognitive decline was observed over the remaining 12 months (ADAS-cog=-1.6±7.6; MMSE=0.8±4.2). AEs were predominantly gastrointestinal and occurred in 7.3% of patients. Conclusions: MLC601 showed good tolerability and promising effects on cognitive function in AD patients during 18 months of treatment.
Cited by 8
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Hossein Pakdaman, Koroush Gharagozli, Mehdi Abbasi · Dementia and Geriatric Cognitive Disorders Extra · 2018
Christopher L.H. Chen, Qingshu Lu, Rajesh Babu Moorakonda · Journal of the American Medical Directors Association · 2022
Hossein Pakdaman, Ali Amini Harandi, Mehdi Abbasi · Dementia and Geriatric Cognitive Disorders Extra · 2017
Christopher L.H. Chen, Purabi Reang Sharma, Boon Yeow Tan · Alzheimer's & Dementia: Translational Research & Clinical Interventions · 2019
Hossein Pakdaman, Ali Amini Harandi, Koroush Gharagozli · Current Aging Science · 2023
Narayanaswamy Venketasubramanian, Ramesh Kumar, Lyna Soertidewi · BMJ Open · 2015
Hossein Pakdaman, Ali Amini Harandi, Hamidreza Hatamian · Dementia and Geriatric Cognitive Disorders Extra · 2015
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