Development and Characterization of Liposome-Enriched Ketoprofen Liposomal Hydrogels
Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja
Journal of Pharmaceutical Research International · pp. 1–7 · Published 25 Apr 2019
10.9734/jpri/2019/v27i130159Abstract
The purpose of this study was to develop liposome-enriched Ketoprofen liposomal hydrogels and carry out in vitro release profile experiment. The aim was to achieve sustained topical drug delivery for extended time interval from liposomal gels. Phosphatidylcholine, Cholesterol and Ketoprofen were dissolved in chloroform/methanol (2:1, v/v) mixture and subsequently transferred to a flask attached to rotavapor. The liposomes were assessed for particle size and percent drug entrapment. F-7 and F-8 batches were found to be optimized batches having optimum sizes, drug entrapment efficiencies and cumulative drug releases. F-8 batch was further evaluated for stability. The results show that the prepared liposomes of Ketoprofen might turn out to be potential candidates for effective and safe sustained drug delivery thereby resulting in the reduction of dosing frequency.
Cited by 1
Shruthi Puchakayala, Abbaraju Krishna Sailaja · Current Nanomedicine · 2021
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