Post Vaccination Immune Response Potentiation against Blue Tongue Vaccination with Stresomix in Deccani lambs and Sheep

Abstract

Aim: The aim of the study was to determine the immunopotentiatory effect of Stresomix, a polyherbal anti stress, immunomodulatory formulation against blue tongue vaccination. The hypothesis was that antistress, adaptogenic and immunomodulatory properties of Stresomix constituent herbs viz. Magnifera indica, Withania somnifera and Phyllanthus emblica would enhance the immune response in deccani lambs and sheeps. Study Design: Total 12 lambs and 12 adult deccani sheep were selected for the study. Vaccination was done with inactivated pentavalent Blue tongue vaccine at 1ml per animal subcutaneously. Place and Duration of Study: The experiment was conducted in Central Research Institute for Dry Land Agriculture, Santoshnagar, Hyderabad, India in Deccani breed of sheeps. Methodology: The parameters viz. antibody titre and serum biochemical parameters were studied statistically. Results: In deccani lambs, increase in the antibody titre against blue tongue (BT) in Stresomix supplemented group II (89.08) was significantly (P<0.01) higher as compared to lambs in untreated group I (69.88). Similarly, In adult deccani sheep, significant (P<0.01) increase in antibody titre was obtained in Stresomix supplemented group II (84.57) in comparison of untreated control group I (57.88) Conclusion: The antibody titre determination and serum biochemical analysis revealed that the Stresomix did not change the biochemical profile so it is safe to use Stresomix for improving post vaccination immune response in sheep.