Chemical Composition, Genotoxicity and Antimicrobial Activities of Dracocephalum kotschyi Boiss against OXA-48 Producing Klebsiella pneumoniae Isolated from Major Hospitals of Kurdistan Province, Iran
Pegah Shakib, Morovat Taherikalani, Rashid Ramazanzadeh
Microbiology Research Journal International · pp. 1–8 · Published 21 Jun 2018
10.9734/MRJI/2018/42064Abstract
Aims: Dracocephalum kotschyi Boiss is a flowering plant that the biological activities of the declared species D. kotschyi such as a warm herbal medicine for rheumatoid diseases, headaches, congestion, stomach disorders, liver treatment, and other usages. The current study aims to investigate the chemical composition, genotoxicity, and antimicrobial activity of Dracocephalum kotschyi Boiss against OXA-48 producing K. pneumoniae isolated in Kurdistan province, Iran. Methodology: Fourteen OXA-48 producing K. pneumoniae were isolated by the PCR assay from major hospitals in Kurdistan province, Iran. GC–MS examination, and in vitro antimicrobial and genotoxicity activities of this essential oil was studied. The data was analyzed using SPSS software and ANOVA. Results: Out of 70 K. pneumoniae clinical strains, 14 OXA-48 producing K. pneumoniae were isolated by the PCR assay. The chemical composition of the oils contained Monoterpene Hydrocarbons, Oxygenated Monoterpenes, Sesquiterpene Hydrocarbons, and Oxygenated Sesquiterpenes. D. kotschyi essential oils showed antimicrobial activity against all of the tested strains, with inhibition values varying from >5000 to 1250 μg/ml for MIC and >5000 μg/ml for MBC in bacteria. In the Ames test, D. kotschyi had a strong anti-mutagenesis effect. Conclusion: According to the findings of the current study, it can be concluded that D. kotschyi essential oils could be applied as a safe antibacterial agent for treatment of OXA-48 producing K. pneumoniae.
Cited by 10
Mohadeseh Almasiro, M. Borhani, M. Salehi · Biologia · 2026
Aazm Shaykh-Samani, A. G. Pirbalouti, M. Yadegari · Journal of Essential Oil-Bearing Plants (JEOBP) · 2023
M. Ghavam · PLoS ONE · 2022
F. Avci, Ilgaz Taştekil, Amit Jaisi · Pathogens and Global Health · 2022
Salome Dini, Qihe Chen, F. Fatemi · Pharmaceutical Biology · 2022
F. Khamesipour, S. Razavi, S. Hejazi · Food Science & Nutrition · 2020
M. Ghavam, Maria Manconi, M. Manca · Journal of Ethnopharmacology · 2020
P. Heydari, M. Yavari, Peyman Adibi · Evidence-Based Complementary and Alternative Medicine · 2019
Khamesipour, Hejazi, Sadraei · 2022
Mustafa Ghanadian, Faham Khamesipour, Seyed Hossein Hejazi · Acta Parasitologica · 2021
Related research
- Prevalence of Methicillin-resistant Staphylococcus aureus among Health Care Workers in Tripoli Hospital, Libya — shares topic coverage
- A Cross Sectional Study on Prevalence of Antibiotic Resistance and Role of Efflux Pumps in Fluoroquinolone Resistance by using Efflux Pump Inhibitors in Isolated Cultures from Poultry, Dairy Farms and MTCC Strains from Reservoirs — shares topic coverage
- Antibiogram Analysis and Characterization of Bacterial Pathogens from Leucorrhea Patients — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
10
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.