Mechanisms of the Aqueous Solvolysis of the Ring-opening of the Lactone Ring of Goniodomin A
B. Andes Hess Jr., Lidia Smentek
International Research Journal of Pure and Applied Chemistry · pp. 9–16 · Published 28 Nov 2022
10.9734/irjpac/2022/v23i6792Abstract
The phycotoxin Goniodomin A is a Dinoflagellate of the Alexandrium genus and is a macrocyclic lactone. It is found widely in sea water and is known to open slowly the lactone in water. The cleavage of the lactone is sensitive to the pH of the water. As one changes the pH from ~6 to 8 its solvolytic rate dramatically increases. Treatment of kinetic data previously published indicates that there are two competing first-order reactions, an SN1 and an intramolecular SN2, which is a pseudo first-order reaction.
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