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Research Article Open access CC BY 4.0

What a Clinical Hematologist Should Know about T Cells?

Sanjeev Kumar Sharma

International Blood Research & Reviews · pp. 20–32 · Published 16 Dec 2020

10.9734/ibrr/2020/v11i430137

Abstract

T cell’s journey begins from the bone marrow and ends in the peripheral tissues by either fighting the infections or residing in the secondary lymphoid organs as memory T cell. Thymus plays most important role in transforming a docile T cell precursor into a warrior. T cell is one of the most important cells in health and disease. Various diseases originate from qualitative or quantitative defects in T cells leading to various inherited and acquired diseases. This simple and short review is focused on the basic understanding and clinical hematologist’s perspective of T cells.

T cells thymus T cell receptor autoimmune diseases severe combined immunodeficiency hematopoietic stem cell transplant graft-versus-host disease leukemia lymphoma aging CAR-T cell checkpoint inhibitors.

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