A Rare Bisalbuminemia Etiology: Cholestatic Hepatitis Case Report

Abstract

Bisalbuminemias consist in a qualitative modification of the albumin pattern aspects, characterized by a duplication of the albumin fraction on the electrophoretic trace of the serum proteins. The prevalence of bisalbuminemia is about 0,03 to 1/1000. They can be inherited or acquired. We report a case of bialbuminemia admitted at the hepato-gastroenterology Department of HMIMV RABAT. This is 52 years old patient, operated for cerebral glioblastoma treated by radio-chemotherapy who consist in Temozolomide, presented cholestatic jaundice two weeks after oral chemotherapy. Electrophoresis serum protein use a capillary electrophoresis system (Capillaries, Sebia) reveals a hypoproteinemia and duplication of the albumin fraction. Bisalbuminemias is a qualitative abnormality of the albumin pattern, diagnosed by electrophoretic trace of the serum proteins. It can be inherited or acquired but globally without pathological effects. The acquired etiology are several whose cholestatic hepatitis induced by drug can be evoked pending a more thorough study.