Biological Activities of Nitro Steroids
Valery M. Dembitsky, Tatyana A. Gloriozova, Vladimir V. Poroikov
Journal of Pharmaceutical Research International · pp. 1–19 · Published 1 Sep 2017
10.9734/JPRI/2017/36196Abstract
The present review describes the biological activities of synthetic nitro steroids. More than fifty biologically active nitro steroids showed an analeptic, antineoplastic, anesthetic, neuroprotector, immunosuppressant, dermatologic properties, and also show other biological activities. The structures and activities of a selection of nitro steroids are reported. Also, some new and additional activities are predicted with the computer program PASS, based on structure–activity relationships (SAR), which point toward new possible applications of these lipid compounds. This review emphasizes the role of the nitro steroids, as an important source of leads for drug discovery.
Cited by 5
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D. A. Kornilov, A. G. Mustafin · Russian Journal of Organic Chemistry · 2024
Valery M. Dembitsky, Tatyana A. Gloriozova, Nick Savidov · Applied Microbiology and Biotechnology · 2018
Valery M. Dembitsky, Nick Savidov, Vladimir V. Poroikov · Applied Microbiology and Biotechnology · 2018
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