Effects of Berberine on Bloog Glucose, Glycated Hemoglobin A1, Serum Insulin, C–Peptide, Insulin Resistance and β– Cell Physiology
Haji Khan Khoharo, Din Muhammad Shaikh, Ghulam Shah Nizamani, Tariq Zaffar Shaikh, Ikramuddin Ujjan, Arslan Ahmed Uqaili
Journal of Pharmaceutical Research International · pp. 36–41 · Published 21 Dec 2020
10.9734/jpri/2020/v32i3630988Abstract
Objective: Determine effects of berberine (BBR) on bloog glucose, glycated hemoglobin A1, serum insulin, C – peptide, insulin resistance and β– cell physiology. Study Design: Experimental study Place and Duration: Department of Physiology Isra University and Animal house of Sindh Agriculture University, Tando Jam from August 2019 to February 2020. Methodology: A sample of 100 adult Wistar male rats was selected according to criteria of study and divided into 5 groups through random technique. Group A – negative controls (N/S 0.9%), Group B – positive control (diabetic rats – Alloxan 120 mg/kg) (i.p), Group C – E; Diabetic rat + BBR (50, 100 and 200 mg/kg) respectively. Blood samples were collected from retro-orbital venous plexus by capillary tube. Sera were separated at 3000 rpm (15 minutes). Insulin resistance (HOMA-IR) and β – cell secretory activity (HOMA-β) were calculated by mathematical formula. Statistical analysis was performed on SPSS version 21.0 (IBM, incorporation, USA) at 95% CI (P≤ 0.05). Results: The present study noted significant improvement of fasting and random blood glucose, glycated HbA1, serum insulin and C –peptide, insulin resistance (HOMA-IR) and β – cell physiology. Conclusion: Berberine (BBR) ameliorates the bloog glucose, glycated hemoglobin A1, serum insulin, c – peptide, insulin resistance and β– cell physiology.
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