Expressional Evaluation of Androgen Receptor in Transitional Cell Carcinoma of Urinary Bladder Patients
Arshad Rahmani, Mohammad Alzohairy, A. K. Mandal, Moshahid A. Rizvi
Journal of Advances in Medicine and Medical Research · pp. 233–238 · Published 23 Jul 2011
10.9734/BJMMR/2011/304Abstract
The study was undertaken to evaluate the possible role of Androgen Receptor (AR) in relation to tumor grade, age, sex and urinary bladder cancer risk. Expression of AR detected by immunohistochemistry in 125 Transitional Cell Carcinoma and 100 control cases. Expression of AR was noticed in 28.8% cases. AR increased with increasing tumor grade. Expression of AR was seen to be significantly higher in male in the age group ≥ 50 years (p < 0.05). AR expression was found to be associated significantly with the tumor grades, age and sex suggesting that AR may be used as prognostic markers in the treatment of urinary bladder carcinomas.
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