Evaluation of the Hepatoprotective Activity of Caesalpinia pulcherrima (Leaf) Against CCl4-Induced Hepatic Injury in Swiss Albino Rat Model

Abstract

The liver is a vital organ that carries out essential tasks. Drinking too much alcohol, not eating well, and having autoimmune illnesses can all damage it. For thousands of years, people have used herbal medicines to treat issues with the liver and other internal organs. Recently, these treatments have been widespread across the world as a way to treat a wide range of liver disorders. This study aimed to see if the ethanolic extract of Caesalpinia pulcherrima leaves might protect the liver from damage caused by CCl4 in albino rats. The study found that SGPT levels were statistically significant (p<0.05) at 300 mg/kg, 600 mg/kg, and 900 mg/kg of Caesalpinia pulcherrima extract. SGOT levels were only significant (p<0.05) at the extract's 600 mg/kg dose. For urea and creatinine, the creatinine levels showed statistically significant results (p<0.05) at dosages of 300 mg/kg and 600 mg/kg.  However, when looking at urea levels, the findings were statistically significant (p<0.05) at 600 mg/kg and 900 mg/kg dosages. The LDL and triglyceride levels did not show statistically significant results at any dose. However, the HDL and total cholesterol levels did show statistically significant results (p<0.05) at the 900 mg/kg dosage of Caesalpinia pulcherrima extract. The study implies that the extract of Caesalpinia pulcherrima might be a new and different way to treat chronic hepatotoxicity.