Exosomes: A Potential Biomarker and Therapeutic Target for the Treatment of Diseases
Bhaskar Debbarma, Sathi Debbarma, Donga Durga Veera Hanuman, M Usha Rani, Sravathi Vemula, Koppula Anusha, B.D.P. Kala Kumar, B. Anil Kumar, Bobbili Rajender
Journal of Advances in Biology & Biotechnology · pp. 655–671 · Published 20 Jun 2024
10.9734/jabb/2024/v27i71026Abstract
Nearly all types of cells release exosomes (30-120 nm, nanosized vesicles), both in diseased and healthy physiological situations. Initially, it was believed that they acted just as “Cellular vacuoles” allowing cells to expel undesired components. Exosome composition and function have been the subject of extensive research since 2007. They are expelled from the majority of cell types and are present in the majority of bodily fluids, such as blood, urine, saliva, breast milk, semen, ascitic fluid, and cell culture media. The study has shown that the exosomal miRNA (MicroRNA) and lncRNA (Long non-coding RNA) content in diseased patients and healthy persons varies. Scientists have successfully discovered in several studies on disease cells that they work as biomarkers, having particular proteins connected to sick pathology. This is due to their role in expressing RNAs, DNAs, and proteins from cell to cell and their presence in most bodily fluids. Exosome-based diagnostic procedures are now being used for the early diagnosis of cancer, diabetes, neurological illnesses, and other conditions. Exosomes have the ability to traverse the blood-brain barrier and may be utilised to deliver therapeutic agents such as proteins, small compounds, viral gene therapy, RNA treatments, and CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing. The aim is to use exosomes as therapeutic drug delivery or carriers as it is much more compatible with the patient's body. Also, it can easily carry the disease information during diagnosis. Our review focuses on two key areas: a) identifying exosomal content from cancer cells as potential diagnostic tools, and b) exploring the possibility of customizing exosomes with therapeutic agents for treatment advantages.
References (93)
- 1 Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells [DOI]
- 2 Extracellular vesicles: Exosomes, microvesicles, and friends [DOI]
- 3 Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids [DOI]
- 4 Exosomes: composition, biogenesis and function [DOI]
- 5 Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). [DOI]
- 6 Exosomes – vesicular carriers for intercellular communication [DOI]
- 7 Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury [DOI]
- 8 Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor [DOI]
- 9 Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6 [DOI]
- 10 A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy [DOI]
- 11 Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells [DOI]
- 12 A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes [DOI]
- 13 Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges [DOI]
- 14 Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain [DOI]
- 15 Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study [DOI]
- 16 Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes [DOI]
- 17 Using exosomes, naturally-equipped nanocarriers, for drug delivery [DOI]
- 18 Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis [DOI]
- 19 Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease [DOI]
- 20 Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio [DOI]
- 21 Bovine milk-derived exosomes for drug delivery [DOI]
- 22 Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies [DOI]
- 23 Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy [DOI]
- 24 Mesenchymal Stem Cells Are Renotropic, Helping to Repair the Kidney and Improve Function in Acute Renal Failure [DOI]
- 25 Exosomes and other extracellular vesicles in host–pathogen interactions [DOI]
- 26 Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease [DOI]
- 27 Extracellular vesicles as drug delivery systems: Lessons from the liposome field [DOI]
- 28 Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator [DOI]
- 29 The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids [DOI]
- 30 Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases? [DOI]
- 31 Comparative analysis of discrete exosome fractions obtained by differential centrifugation [DOI]
- 32 Serum Levels of microRNAs in Patients with Heart Failure [DOI]
- 33 Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo [DOI]
- 34 Paracrine induction of endothelium by tumor exosomes [DOI]
- 35 Pathologic function and therapeutic potential of exosomes in cardiovascular disease [DOI]
- 36 Transferrin recycling in reticulocytes: pH and iron are important determinants of ligand binding and processing [DOI]
- 37 Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine? [DOI]
- 38 Tumor-cell-derived microvesicles as carriers of molecular information in cancer [DOI]
- 39 Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid [DOI]
- 40 Extracellular vesicles – vehicles that spread cancer genes [DOI]
- 41 Functions and application of exosomes.
- 42 Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles [DOI]
- 43 Exosomes and the blood–brain Barrier: Implications for Neurological Diseases [DOI]
- 44 The Role of Exosomes in Breast Cancer [DOI]
- 45 Exosome proteomics reveals transcriptional regulator proteins with potential to mediate downstream pathways [DOI]
- 46 Cell activation and HIV-1 replication in unstimulated CD4+T lymphocytes ingesting exosomes from cells expressing defective HIV-1 [DOI]
- 47 Exosomes: A Bubble Ride for Prions? [DOI]
- 48 Proteomics profiling of cholangiocarcinoma exosomes: A potential role of oncogenic protein transferring in cancer progression [DOI]
- 49 Therapeutic uses of exosomes [DOI]
- 50 Transferrin receptor expression in serum exosomes as a marker of regenerative anaemia in the horse [DOI]
- 51 Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines [DOI]
- 52 Progress in Exosome Isolation Techniques [DOI]
- 53 Biogenesis and function of extracellular vesicles in cancer [DOI]
- 54 Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol [DOI]
- 55 miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges [DOI]
- 56 Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations [DOI]
- 57 Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs [DOI]
- 58 Review on Strategies and Technologies for Exosome Isolation and Purification [DOI]
- 59 Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery [DOI]
- 60 Engineered exosomes from different sources for cancer-targeted therapy [DOI]
- 61 Comparison of small extracellular vesicles isolated from plasma by ultracentrifugation or size‐exclusion chromatography: yield, purity and functional potential [DOI]
- 62 Exosomes: new molecular targets of diseases [DOI]
- 63 Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy [DOI]
- 64 Exosomes as novel bio-carriers for gene and drug delivery [DOI]
- 65 Exosomal long noncoding RNA CRNDE-h as a novel serum-based biomarker for diagnosis and prognosis of colorectal cancer [DOI]
- 66 Exosomes in the Pathology of Neurodegenerative Diseases [DOI]
- 67 An integrated double-filtration microfluidic device for isolation, enrichment and quantification of urinary extracellular vesicles for detection of bladder cancer [DOI]
- 68 CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges [DOI]
- 69 Exosomal lncRNAs as new players in cell-to-cell communication [DOI]
- 70 Therapy resistance mediated by exosomes [DOI]
- 71 Drug loading techniques for exosome-based drug delivery systems. [DOI]
- 72 Exosomes as drug delivery systems: A brief overview and progress update [DOI]
- 73 Manufacturing Therapeutic Exosomes: from Bench to Industry [DOI]
- 74 Recent Advancements in the Loading and Modification of Therapeutic Exosomes [DOI]
- 75 From structures to functions: insights into exosomes as promising drug delivery vehicles [DOI]
- 76 Therapeutic use of curcumin‐encapsulated and curcumin‐primed exosomes [DOI]
- 77 Genome-wide microRNA profiling of bovine milk-derived exosomes infected with Staphylococcus aureus [DOI]
- 78 Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing [DOI]
- 79 Proteome of Glioblastoma-Derived Exosomes as a Source of Biomarkers [DOI]
- 80 Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules [DOI]
- 81 Exosomes as Theranostics for Lung Cancer [DOI]
- 82 Milk exosomes and miRNA cross the placenta and promote embryo survival in mice [DOI]
- 83 Cardiac Fibroblast-Induced Pluripotent Stem Cell-Derived Exosomes as a Potential Therapeutic Mean for Heart Failure [DOI]
- 84 Preparation of Exosomes for siRNA Delivery to Cancer Cells [DOI]
- 85 Deep-Sequencing Identification of MicroRNA Biomarkers in Serum Exosomes for Early Pig Pregnancy [DOI]
- 86 Extracellular Vesicles Loaded miRNAs as Potential Modulators Shared Between Glioblastoma, and Parkinson’s and Alzheimer’s Diseases [DOI]
- 87 Serum-Derived Extracellular Vesicles from African Swine Fever Virus-Infected Pigs Selectively Recruit Viral and Porcine Proteins [DOI]
- 88 Circulating Small Extracellular Vesicle-Derived miR-342-5p Ameliorates Beta-Amyloid Formation via Targeting Beta-site APP Cleaving Enzyme 1 in Alzheimer’s Disease [DOI]
- 89 Proteomic content of circulating exosomes in dairy cows with or without uterine infection [DOI]
- 90 Circulating exosomes may identify biomarkers for cows at risk for metabolic dysfunction [DOI]
- 91 Exosomes: A Paradigm in Drug Development against Cancer and Infectious Diseases [DOI]
- 92 The Role of Biochemical Markers in the Prediction of Preeclampsia [DOI]
- 93 Ykl-40: A Potential Biomarker And Therapeutic Target For Breast Cancer Diagnosis And Therapy [DOI]
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