Effects of Aloe vera Gel on the Homeopoietic, Biochemical and Histological Parameters and Bone Marrow of Wistar Rats

Abstract

Aloe vera is well known for its medicinal properties. This plant is one of the richest natural sources of health for human beings. The chemistry of the plant has revealed the presence of more than 200 different biologically active substances. The aloe plant is said to have effect on so many organs including the homeopoietic tissue and organs. This study was conducted to confirm this assertion. A total of 16 male albino rats weighing between 120-150g were grouped into four (4) with 5 rats each (A, B, C & D). Group A to C served as the experimental groups while group D served as the control group, which received food and water only. Group A, B and C received 250mg/kg, 500mg/kg, and 750mg/kg of the extract, respectively for 14 days. Group D served as the control was given clean water and normal feed. The rats were then sacrificed under anesthesia and the blood obtained was subjected to the biochemical investigation. The bone marrow through the bone was obtained and preserved in formalin for subsequent histopathological processing examination. Our results show that Aloe vera has positive effect (by increasing the count) on the white blood cells, but decreases the Red blood cells count, packed cell volume counts, which may lead to anaemia in prolonged ingestion. Aloe Vera decrease red blood cells production, but enhance platelet production, also encourage presence of mild fatty tissues in the bone marrow.