Optimized State of Extraction of Phenolic Compounds of Boscia senegalensis (Pers.) Lam. ex Poir. and Evaluation of their Antihyperglycemic Activities

Abstract

Introduction: The resurgence of diabetes and some side effects of synthetic drugs used for its treatment led us to study a plant used in traditional medicine, Boscia senegalensis for its treatment. This work aims to optimize the aqueous extract of B. senegalensis and to evaluate its antihyperglycemic activity. Methods: For this study, several phytochemical assays were performed, to obtain extracts with better concentrations and good effectiveness. Results: The analyses allowed to see the possible correlations between the variables (time and mass of the powder) then the answers show that the effects have P values 0.05. This indicates that they are significantly different from zero to 95.0% confidence level with different optimal areas for good extraction of phenolic compounds from this plant. Several experiments are performed on normoglycemic rats on the model of oral-induced hyperglycemia. The extract is administered at a single dose of 200 mg/kg in proportion to the animal’s weight. Blood sugar normally varies up to a level where the extract has its effects. The peaks are reached at 30 min showing here that the extracts significantly lower blood sugar. Conclusion: The extracts significantly reduced glycemia taking into account optimization conditions.