Cichorium intybus Inhibits Doxorubicin- Induced Myocardial fibrosis in Wistar Rats Via Inflammatory Markers and Collagen Repression
Vishwadeep Shelke, Ghanshyam Jadhav, Amol Mhaske, Vidya Shirsath, Sagar Kamble, Awais Sayyad
European Journal of Medicinal Plants · pp. 51–61 · Published 1 Apr 2021
10.9734/ejmp/2021/v32i230372Abstract
Many allopathic medicines demand to remedy for myocardial fibrosis but fail to fulfill the purpose, because of side effects and high cost. Herbal medicine has fewer side effects and natural herbs are considered safe when compared with synthetic medicines. The present study aimed to study the effect of extract of Cichorium intybus on experimentally induced myocardial fibrosis in Wistar rats. The objective of the present study was to find out the possibilities of the use of Cichorium intybus as a supportive/ protective medicine and to explore the possible toxicities of Cichorium intybus in these models. Myocardial fibrosis was induced by Doxorubicin (2.5 mg/kg, i.p. Thrice a week) rats. Blood pressure, Collagen levels, Left ventricle weight index were effectively reduced in animal groups treated with the extract. The effect of extracts was studied on various oxidative stress markers like SOD, CAT, LOP, and NO. Extract of Cichorium intybus was shown significantly decreased in blood pressure and significantly shows the antioxidant effect when compared to the hypertensive control group.
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