Effect of Combined Aqueous Leaf Extract of Mentha spicata and Murray Koenigii on Acetaminophen (Paracetamol) Induced Hepatic Damage on Wistar Rats

Abstract

The study investigated the effect of combined leaves extract of Mentha spicata and Murray koenigii leaves on acetaminophen induced hepatic damage on wistar rat. Twenty five (25) wistar rats with weights range of 100g-130g were used for this study. They were obtained from the animal house of the Department of Biochemistry, University of Port Harcourt, rivers State, Nigeria. They were kept in the animal house of the University. They had free access to water and feed during the period of the experiment. Treatment of test animal with 80mg/kg, 120mg/kg, 150mg/kg dose of the leaf extract showed ameliorative effect on the animals with specified dose producing the best result. The significant increase in liver marker enzymes (AST, ALP, and AST) activities of acetaminophen-induced rats caused by liver injuries which resulted in leakage of liver enzymes to the extra hepatic tissue due to compromised liver architecture and permeability. The improvement of the effect of the acetaminophen suggests that these combined leaves action can be of valuable use in the management of hepatic injury caused by this toxic action.