Granulosa Cell Tumour of Ovary: Review of Cases at Tertiary Care Centre

Abstract

Introduction: Granulosa cell tumours of the ovary are rare malignancies representing 2-3% of all malignant ovarian tumours. Objective: To review the clinical characteristics and management of granulosa cell tumour of ovary. Materials and Methods: The medical records of nine women diagnosed with granulosa cell tumour of ovary from June 2005 to October 2015 in the Department of Gynecologic Oncology of our institution were retrospectively reviewed. Results: The mean age of the women was 42 years. They presented with various symptoms: menorrhagia, post-menoausal bleeding, abdominal distension and pain abdomen. In one patient who presented with abdominal pain and distension with breathlessness, chest X-ray showed? metastatic lesions and received neoadjuvant chemotherapy. Eight patients underwent primary surgery with complete staging in six patients. Two patients presented with haemoperitoneum and underwent emergency laparotomy. Four patients had ascites. Mean ovarian tumour size was 14 cms (range 4-30 cms). Fertility sparing surgery was done in one patient. The number of patients in various stages were I - 4(IA-3, IC2-1); IIA-1; IIIC-1; IVB-1 and unknown - 2 accord­ing to the International Federation of Gynecology and Obstetrics (FIGO) 2014 criteria. The maximum follow up duration was 65 months. Recurrence was observed after 3 years in two patients (one stage IA and other stage IIIC). Conclusion: Granulosa cell tumours are classified into two types by juvenile and adult variant. GCT has low malignant potential and known to recur after many years of apparent clinical cure. Therefore, long term follow up with clinical examination and tumour marker is recommended.