Lower Urinary Tract Infections among Patients Diagnosed of Benign Prostate Hyperplasia in Federal Medical Centre, Bida, North Central, Nigeria

Abstract

Objective: This study was aimed to identify the aetiology of bacteria associated with Benign Prostate Hyperplasia (BPH) and to determine the antimicrobial susceptibility pattern of the isolated organisms in the community. Study Design: Data were obtained from Medical Microbiology Department register from February 2009 through December 2013, and was exempted from ethical approval. Urine samples were collected from a total of 536 patients with indwelling urinary catheter on hospital admissions that were clinically diagnosed of BPH. Subjects were between the ages of 41 and 100 years. Data was coded, computed and analyzed using SPSS version 16.0 and p values ≤0.05 was considered to be statistically significant. Results: Our research showed that the incidence of urinary tract infections in this study population was (62.5%), and statistically not significant (p- value = 0.296, mean age=5.13, mode=4.00 and S.D ±2.03). Escherichia coli 247(67.7%) was the most prevalent uropathogen followed by Staphylococcus aureus 34(9.3%), Pseudomonas species 29(7.9%), Klebsiella species 10(2.7%), Proteus species 10(2.7%), Candida albicans 4(1.1%) and Staphylococcus albus 1(0.3%) being the least isolates. The highest uropathogen was susceptible to Nitrofurantoin (61.9%) followed by Levofloxacin (44.1%) and least susceptible to Gentamycin (12.1%), Nalidixic acid (12.1%), Augmentin (7.7%) and Ampicillin (0.4%). Conclusion: Our research showed high incidence rate of 62.5% of UTIs among patients with indwelling urinary catheter and diagnosed of benign prostate hyperplasia in our community. This is of serious concern to all stake holders in health industry.