In vitro Growth of Trichophyton Rubrum in the Presence of 80% Ethanolic Extract of Grapefruit Pepins as Antifungal Agent

Abstract

Introduction: Many modern antifungal drugs have limits in terms of germ resistance, and to remedy this, plant compounds are being explored to find new more effective principles. Aim: With the aim of complementing the efforts of modern medicine against viral, bacterial, parasitic and fungal diseases, the plant extract of 80% hydroalcoholic grapefruit seed extract of Citrus paradisi was tested on the in vitro growth of Trichophyton rubrum. Methods: Antifungal tests were carried out on Sabouraud medium, to which the plant extracts were incorporated using the double dilution method in inclined tubes. A 10 µL volume of the Trichophyton rubrum suspension was inoculated on the culture medium contained in the test tubes. Results: Results showed that Trichophyton rubrum was sensitive to the 80% hydroethanolic extract of Citrus paradisi in a dose-dependent manner. Conclusion: The hydroethanolic extract may be a source for the development of Traditional Improved Medicines (TIM) against skin mycosis.