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Research Article Open access CC BY 4.0

Hypoglycaemic Effect of Lycopene in Streptozotocin-Induced Diabetic Wistar Rats

Ejike Daniel Eze, Aliyu Mohammed, Yusuf Tanko, Abubakar Ahmed, Karimah Mohammed Rabiu

Journal of Advances in Medicine and Medical Research · pp. 762–770 · Published 31 Mar 2015

10.9734/BJMMR/2015/15908

Abstract

Aim: The study was designed to investigate the hypoglycaemic potential of lycopene in streptozotocin (STZ)-induced diabetic Wistar rats. Methodology: To achieve this, a total of thirty (30) adult Wistar rats of both sexes were used. The animals were made diabetic by single intraperitoneal injection of freshly prepared (60 mg/kg body weight) of STZ. Diabetes was confirmed by the presence of high blood glucose ≥ 200 after 72 hr. Diabetic animals were divided into six (6) groups (1, 2, 3, 4, 5 and 6) comprising five animals each. Animals in Group 1 (Diabetic control) and Group 2 (Normal control) received 0.5 ml of olive oil, while those in groups 2, 3, 4, 5 and 6 were administered 10, 20, 40 and 2 mg/kg b w of lycopene and glibenclamide respectively orally once daily for a period of four weeks. After the last day of treatments, all animals were sacrificed and blood samples collected and the serum separated for determination of serum insulin concentration. The liver tissue was excised and homogenized in equivalent volumes of phosphate buffer for the determination of hepatic glucokinase enzyme activity. Results: The results obtained showed that lycopene at all doses significantly (P < 0.05) decreased the blood glucose concentration steadily from (431.4±48.84 mg/dL) to (171.1±7.65, 118.4±1.97 and 100.8±6.89 mg/dL) after four weeks of treatment. The Serum insulin level was increased from (3.02±0.24 µIU/mL) to (4.02±0.70, 3.96±1.41 and 5.06±0.96 µIU/mL), but was not significant (P>0.05), when compared with diabetic control animals. The activity of hepatic glucokinase was significantly (P<0.05) increased from (8.78±1.11 ng/mL) to (11.96±0.54, 14.23±0.88 and 15.78±0.27 ng/mL), when compared with diabetic control group. Conclusion: It is therefore, suggested that antidiabetic-activity may be linked to enhanced glucokinase enzyme activity and not due to increased serum insulin level as the elevation was not statistically significant (P > 0.05) when compared with the diabetic control group. It is recommended that, lycopene may be used as a dietary component in controlling sustained hyperglycaemia in diabetes.

Diabetes mellitus lycopene hypoglycaemia insulin rats glucokinase

References (32)

  1. 1 The American journal of clinical nutrition [DOI]
  2. 2 Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus [DOI]
  3. 3 Lycopene is more bioavailable from tomato paste than from fresh tomatoes [DOI]
  4. 4 Lycopene and cardiovascular disease [DOI]
  5. 5 Consequences of the diabetic status on the oxidant/antioxidant balance.
  6. 6 Molecular Physiology of Mammalian Glucokinase [DOI]
  7. 7 The global epidemiology of non-insulin-dependent diabetes mellitus and the metabolic syndrome [DOI]
  8. 8 Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats [DOI]
  9. 9 Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin-induced diabetic rats [DOI]
  10. 10 Early diabetic neuropathy: Triggers and mechanisms [DOI]
  11. 11 Hyperglycemia Induces Oxidative Stress and Impairs Axonal Transport Rates in Mice [DOI]
  12. 12 Stimulation by insulin of glucokinase gene transcription in liver of diabetic rats. [DOI]
  13. 13 Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats [DOI]
  14. 14 Lycopene II—Effect on Osteoblasts: The Carotenoid Lycopene Stimulates Cell Proliferation and Alkaline Phosphatase Activity of SaOS-2 Cells [DOI]
  15. 15 Antidiabetic effect of ethanolic leaf extract of Phyllanthus amarus in alloxan induced diabetic mice
  16. 16 Oxidative Stress in Diabetes Mellitus [DOI]
  17. 17 Effect of long term supplementation of tomatoes (cooked) on levels of antioxidant enzymes, lipid peroxidation rate, lipid profile and glycated haemoglobin in Type 2 diabetes mellitus [DOI]
  18. 18 Effect of Lycopene Application in Rats with Experimental Diabetes Using Lipoprotein, Paraoxonase and Cytokines [DOI]
  19. 19 Lycopene supplementation elevates circulating insulin-like growth factor–binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer [DOI]
  20. 20 Chemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell Death [DOI]
  21. 21 The effects of dietary lycopene supplementation on human seminal plasma [DOI]
  22. 22 Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect [DOI]
  23. 23 Lycopene and Lutein; A review for their Chemistry and Medicinal Uses
  24. 24 Potential Role of Lycopene in the Treatment of Hepatitis C and Prevention of Hepatocellular Carcinoma [DOI]
  25. 25 Effect of Lycopene Administration on Plasma Glucose, Oxidative Stress and Body Weight in Streptozotocin Diabetic Rats [DOI]
  26. 26 Effect of Experimental Diabetes Mellitus on Plasma Lactate Dehydrogenase and Glutamic Oxaloacetic Transaminase Levels in Rabbits
  27. 27 Effect of lycopene on the vascular endothelial function and expression of inflammatory agents in hyperhomocysteinemic rats.
  28. 28 Assessment of protein oxidation in women using raloxifene [DOI]
  29. 29 Comparative sensitivity to inorganic phosphate of sucrose to starch conversion in sorghum and wheat grains raised through liquid culture.
  30. 30 African Journal of Traditional, Complementary and Alternative Medicines [DOI]
  31. 31 International Urology and Nephrology [DOI]
  32. 32 Journal of Neuroscience and Behavioral Health [DOI]

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