Triterpenoids from Poria cocos and Their Potential In vitro Hepatoprotective Effects
Yihai Wang, Guoqiong Wang, Xiaomin Yi, Xiangjiu He
Journal of Complementary and Alternative Medical Research · pp. 1–7 · Published 6 Dec 2017
10.9734/JOCAMR/2017/38016Abstract
Aims: To isolate triterpenoids from the surface layer of Poria cocos and evaluate their hepatoprotective activities in vitro. Study Design: Triterpenoids were isolated and identified from the surface layer of Poria cocos. Their effects on alcohol induced-liver injury models were investigated in vitro. Place and Duration of Study: School of Pharmacy, Guangdong Pharmaceutical University, between September 2013 and December 2013. Methodology: Triterpenoids were purified by Silica gel, ODS as well as HPLC chromatography and characterized by MS, 1D and 2D NMR. The hepatoprotective effects of the isolated compounds against alcohol induced-liver injury were investigated in L-02 cell line. Results: Eight triterpenoids were isolated and identified from the surface layer of Poria cocos (1–8), Compounds 2, 3, 6 showed potent protective effects against ethanol-induced injury on L-02 cells. Conclusion: This study suggests that triterpenoids from the surface of Poria cocos could protect L-02 cells from death induced by alcohol and suitable for alcohol induced-liver injury patients as medicine or functional food, which would be a new candidate for the treatment of alcoholic liver disease.
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