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Research Article Open access CC BY 4.0

Identification and Evaluation of Neuroprotective Effect of a Butanol Extract from Centella asiatica (L.) URB

Tru Van Nguyen, Nguyet Thi Doan, Nhi Hanh Ngo, Hanh Van Nguyen, Duong Hoang Nguyen

Asian Journal of Biochemistry, Genetics and Molecular Biology · pp. 32–41 · Published 11 Jan 2025

10.9734/ajbgmb/2025/v17i1435

Abstract

In recent years, herbal plants have been widely used in the treatment of neurodegenerative diseases. Centella asiatica (l.) urb is a significant medicinal plant renowned for its diverse ethnomedicinal applications. The present study evaluated biological activities for neuroprotective effect of C. asiatica. In summary, Centella asiatica (l.) urb was identified using DNA barcoding such as matK and rbcL genes. The sequences obtained were then compared through a similarity search using the NCBI GenBank database. Notably, the extracts of Centella asiatica exhibited high acetylcholinesterase inhibitory activity. Furthermore, the butanol extract of C. asiatica demonstrated the most significant neurotrophic effects in preliminary cell-based screenings, particularly in promoting neurite outgrowth in C6 cells. These findings suggest that C. asiatica holds considerable promise as a potential candidate for the development of pharmacological treatments for neurodegenerative diseases.

Centella asiatica (l.) urb neurodegenative diseases AChE inhibitory neurite outgrowth

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