Variation in Blood Indices in Cases of Anemias Coexisting with HbE from Eastern India

Abstract

Hemoglobin E is one of the most common forms of abnormal hemoglobin, related to hemoglobinopathies in the world. It can result in a heterogeneous group of disorders ranging from asymptomatic to severe anemia with regular blood transfusion dependency. HbE trait and HbE/E are mild disorders, as compared to other form of β globin defect. But when HbE combine with other forms of anemia, it can yield variety of clinical manifestations. Not only these various clinical changes caused by HbE hemoglobinopathy in homozygous or heterozygous forms, but also the standard haematological parameters changes interestingly often leading to misdiagnosis, when other anemia like Aplastic Anemia and Iron Deficiency Anemia are coexisted with HbE allele. In this paper, we have tried to address how different anemias along with HbE hemoglobinopathy can bring about changes in different hematological parameters. We have categorically tried to address the issue by comparing the specific and relevant hematological parameters of these HbE hemoglobinopathy patients, with presence of others forms of anemia, like aplastic anemia, iron deficiency anemia. This paper can give very significant clues to both the future researchers and clinicians to diagnose the HbE hemoglobinopathy with more certainty and clarity, when other forms of anemia co-existed with HbE.