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Research Article Open access CC BY 4.0

Recent Advances in Application of Alkoxy Radical in Organic Synthesis

Munsaf Ali, Shi Sewell, Juncheng Li, Ting Wang

Organics · pp. 459–489 · Published 28 Sep 2023

10.3390/org4040033

Abstract

Alkoxy radicals have been identified as versatile intermediates in synthetic chemistry in the last few decades. Over the last decade, various catalytic processes for the in situ generation of alkoxy radicals have been explored, leading to the development of new synthetic methodologies based on alkoxy radicals. In this review, we provided a comprehensive review of recent developments in the utilization of alkoxy radicals in diverse organic transformations, natural product synthesis, and the late-stage modification of bioactive molecules through the implementation of the photoredox methodology.

Alkoxy group Radical Organic synthesis Chemistry Combinatorial chemistry Organic chemistry Catalysis Alkyl

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