Insight Cross-talk between p53 and Toll-like Receptor

Abstract

Toll-like receptors (TLR) are one of the most-studied receptors for their role in innate immunity. TLRs are reported to binds with conserved pathogen-associated molecular patterns (PAMPS). TLRs and PAMPS interaction leads to several downstream proteins' activation, which further signaled to the various transcription factors. Moreover, these transcription factors play an important role in synthesizing proteins that control cellular immunity. Various TLR proteins have been reported in humans as well several other organisms. Studies show that apart from inducing innate immunity, TLRs have also played an important role in the induction of many proteins, and protein networks associated with initiation apoptosis and cancer prevention. P53 is one of the most important and widely studied proteins. Moreover, various experimental studies suggest that p53 has an important role as tumor suppressor. It is reported that more than 50% of cancerous growth are associated with the mutation of p53. It acts as transcription activator for several proteins that are mostly associated with glycolysis, cell cycle, cell differentiation, apoptosis and cancer. In the present review, we present an insight cross-talk between p53 and Toll-like receptor. In addition, the well-characterized role of p53 in the regulation of the immune system is studied, which would provide a new insight to the broad understanding of p53 role in human biology. Moreover, the association of the p53 and TLRs can lead to therapeutic interventions.