Analytical Method Development and Validation for Estimation of Silymarin in Tablet Dosage form by HPLC
Sneha Singh, Mohit Saini, Jitender K. Malik, Amit Kumar
Asian Journal of Applied Chemistry Research · pp. 22–31 · Published 19 May 2020
10.9734/ajacr/2020/v5i330135Abstract
Silymarin is extracted from the Silybum marianum (milk thistle) plant C25 containing flavonoid mixture. It is mainly used for its effect in liver disease. The HPLC of silymarin tablet had been validated for precision, accuracy (recovery), selectivity & Linearity. In the present study, an attempt was made to provide a newer, simple, sensitive, precise and low cost HPLC method for the effective quantitative determination of silymarin as an active pharmaceutical ingredient as well as in pharmaceutical preparations without the interferences of other constituent in the formulations. HPLC method is developed and validated for various parameters as per ICH guidelines. The validated method was effectively useful to the commercially accessible pharmaceutical dosage form, yielding extremely good and reproducible result.
Cited by 7
Suraj J. Patil, Sneha S. Kharat, Saniket B. Wadgaonkar · Asian Journal of Pharmaceutical Analysis · 2024
Sandeep Kr Maharana, Nasir Khan, Pinaki Sengupta · 2025
Heba K. Ashour, Shaza M. Kamel, Fawzy El-Yazbi · Sustainable Chemistry and Pharmacy · 2023
Mahmood Ahmed, Abdullah, Eisha Eiman · Microchemical Journal · 2024
Srinivas Reddy Jitta, Salwa, Lalit Kumar · ASSAY and Drug Development Technologies · 2021
Rushikesh Sanjay Shewale, Shyam Sudhakar Gomte, Aakanchha Jain · Archiv der Pharmazie · 2024
Showing 6 of 7 known citations — external sources report more than can currently be individually listed.
Related research
- Real Time Polymerase Chain Reaction versus Enzyme Linked Immunosorbent Assay in the Diagnosis of Cytomegalovirus Infection in Pregnant Women — shares topic coverage
- Home Recording And Video Selection: Their use In A Low-Resource Setting For Epilepsy Diagnosis — shares topic coverage
- Laboratory Performance Evaluation of Wantai HIV 1/2 Rapid Test Kit — shares topic coverage
- Performance of WRF’S Microphysics Options to Increase the Medium Range Rainfall Forecast Accuracy in Tamil Nadu Cauvery Delta Zone — shares topic coverage
- Remote Sensing and GIS Based Crop Acreage Estimation of the Rabi Season Growing Crop of the Middle Gujarat (India) — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
7
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.