Evaluation of NGASL Biomarkers and Some Biochemical Parameters in Patients with Renal Disorders in Ramadi City, Iraq

Abstract

This study was designed to determine the effect or the relationship between neutrophil gelatinase-associated lipocalin (NGASL) and some kidney function parameters in kidney disorder patients to detect the level of serum markers in kidney disorder patients (acute glomerular nephritis, renal calculi, and acute renal failure) in Ramadi City. 120 male and female samples participated; the present study was divided into three groups of 90 patients (30 acute glomerular nephritis, 30 renal calculi, and 30 acute renal failure) and 30 healthy control individuals. The serum NGASL was measured using an ELISA technique. Kidney function tests (serum creatinine and serum urea, HB, and WBC)) were also measured by the quantitative method. The result showed low significant (p > 0.001) differences in hemoglobin and WBC percent in the acute renal failure group compared with other groups, and when compared between the studied groups, the results showed high significant (p< 0.001) differences in urea and creatinine concentration in the acute renal failure group compared with the AGN and RC groups. On the other hand, the result showed high significant(p<0.001) differences in level of NGASL in Acute Renal Failure group compare with others groups. The correlation between parameters showed a higher negative correlation between Hb with urea, creatinine, and NGASL (r = -0.571, -0.508, and -0.463), respectively. In addition to the higher correlation between urea and creatinine with NGASL (r = 0.670, 0.406),. So can be considered NGASL a biomarker for kidney injury or kidney disorder. That may indicate the NGASL effect of renal disease and may be used as predictive parameters for kidney diseases.