Microwave-Assisted Catalytic Transfer Hydrogenation of Chalcones: A Green, Fast, and Efficient One-Step Reduction Using Ammonium Formate and Pd/C

References (56)

1. 1 Nie, 2021, Recent Advances in Catalytic Transfer Hydrogenation with Formic Acid over Heterogeneous Transition Metal Catalysts [DOI]
2. 2 Tafesh, 1996, A review of the selective catalytic reduction of nitroaromatic compounds [DOI]
3. 3 Magano, 2012, Large-scale carbonyl reductions in the pharmaceutical industry [DOI]
4. 4 Takada, S.C.S., Blassioli-Moraes, M.C., Borges, M., Laumann, R.A., Maravalho, I.V., and Silva, W.A. (2025). Microwave-assisted enantioselective synthesis of (2R,5S)-theaspirane: A green chemistry approach. Molecules, 30. [DOI]
5. 5 Cabaj, 2007, Development of a commercial process to produce oxandrolone [DOI]
6. 6 Hett, 1998, A practical and efficient method for the reduction of aldehydes and ketones [DOI]
7. 7 Fuenfschilling, 2006, An Improved Manufacturing Process for Fluvastatin [DOI]
8. 8 Hilborn, 2001, A practical asymmetric synthesis of (R)-fluoxetine and its major metabolite (R)-norfluoxetine [DOI]
9. 9 Andrade, 2007, Computational approach for the design of AP1867 analogs: Aiming at new synthetic routes for potential immunosuppressant agents [DOI]
10. 10 Hansen, 2003, A scalable asymmetric synthesis of (S)-3-[3-(methylsulfonyl)phenyl]-3-(phenyl)propan-1-amine [DOI]
11. 11 Mandal, 2002, New synthetic route to (1R)-cis permethrin, (1R)-cis cypermethrin and (1R)-cis deltamethrin from (+)-3-carene
12. 12 Larock, R.C. (2018). Comprehensive Organic Transformations, Wiley. [3rd ed.]. [DOI]
13. 13 Mohammadian, 2021, Synthesis of CoFe2O4@Pd/Activated carbon nanocomposite as a recoverable catalyst for the reduction of nitroarenes in water [DOI]
14. 14 Hudlický, M. (1996). Reductions in Organic Chemistry, American Chemical Society. [2nd ed.].
15. 15 Wang, P., Ma, Y., Shi, Y., Duan, F., and Wang, M. (2023). Application of metal-based catalysts for semi-hydrogenation of alkynol: A review. Materials, 16. [DOI]
16. 16 Mohamadi, 2013, Regioselective and chemoselective reduction of α,β-unsaturated carbonyl compounds by NaBH4/Ba(OAc)2 [DOI]
17. 17 Chandrasekhar, 2014, Selective aldehyde reduction in ketoaldehydes with NaBH4–Na2CO3–H2O at room temperatures [DOI]
18. 18 Shang, 2012, Synthesis of optically active secondary alcohols via asymmetric transfer hydrogenation [DOI]
19. 19 Bagal, 2011, An efficient and heterogeneous recyclable palladium catalyst for chemoselective conjugate reduction of α,β-unsaturated carbonyls in aqueous medium [DOI]
20. 20 Luo, 2021, Chemoselective transfer hydrogenation of α,β unsaturated ketones catalyzed by iridium complexes [DOI]
21. 21 Li, 2018, Transition-metal-free highly chemo-selective and stereoselective reduction with Se/DMF/H2O system [DOI]
22. 22 Huang, 2019, Electrochemical 1,4-reduction of α,β-unsaturated ketones with methanol and ammonium chloride as hydrogen sources [DOI]
23. 23 Hosseini, 2023, Chemoselective reduction of α,β-unsaturated carbonyl compounds via a CS2/t-BuOK system: Dimethyl sulfoxide as a hydrogen source [DOI]
24. 24 Andrade, 2006, One-step reduction of chalcones to saturated alcohols by ammonium formate/palladium on carbon: A versatile method [DOI]
25. 25 Wang, 2018, Hydroxide-membrane-coated Pt3Ni nanowires as highly efficient catalysts for selective hydrogenation reaction [DOI]
26. 26 Song, 2019, Chemoselective hydrogenation of α,β-unsaturated carbonyls catalyzed by biomass derived cobalt nanoparticles in water [DOI]
27. 27 Chen, 2015, A base-controlled chemoselective transfer hydrogenation of α,β-unsaturated ketones catalyzed by [IrCp*Cl2]2 with 2-propanol [DOI]
28. 28 Simion, 2020, Reduction of α,β-unsaturated carbonyl compounds and 1,3-diketones in aqueous media, using a Raney Ni Al alloy [DOI]
29. 29 Ding, 2013, Chemoselective transfer hydrogenation of α,β-unsaturated ketones catalyzed by pincer Pd complexes using alcohol as a hydrogen source [DOI]
30. 30 Koenig, 2003, Ammonium formate/palladium on carbon: A versatile system for catalytic hydrogen transfer reductions of carbon–carbon double bonds
31. 31 Finta, 2009, Unexpected chemoselectivity in the rhodium-catalyzed transfer hydrogenation of α,β-unsaturated ketones in ionic liquids [DOI]
32. 32 Rousslang, 2011, A simple borohydride-based method for selective 1,4 conjugate reduction of α,β-unsaturated carbonyl compounds
33. 33 Adhikari, S., Nath, P., Deb, V.K., Das, N., Banerjee, A., Pathak, S., and Duttaroy, A.K. (2025). Pharmacological potential of natural chalcones: Recent studies and future perspective. Front. Pharmacol., 16. [DOI]
34. 34 Gomes, 2018, Potential herbicidal effect of synthetic chalcones on the initial growth of sesame (Sesamum indicum L.) and Brachiaria (Urochloa decumbens (Stapf) R. D. Webster) [DOI]
35. 35 Yang, 2023, Recent progresses in chalcone derivatives as potential anticancer agents [DOI]
36. 36 Gomes, 2019, Structure–Activity relationship study of antitrypanosomal chalcone derivatives using multivariate analysis [DOI]
37. 37 Silva, 2013, Biological and structure-activity evaluation of chalcone derivatives against bacteria and fungi [DOI]
38. 38 Shalaby, 2023, Synthesis, reactions and application of chalcones: A systematic review [DOI]
39. 39 Dziągwa-Becker, M., Oleszek, M., Zielińska, S., and Oleszek, W. (2024). Chalcones—Features, Identification Techniques, Attributes and Application in Agriculture. Molecules, 29. [DOI]
40. 40 León, L., Cebrián, L., Monge, Á., Cacho, M., and Sanmartín, C. (2025). Flavonoids, Chalcones, and Their Fluorinated Derivatives: A Review of Their Potential as Anti-Inflammatory, Antidiabetic, Anticancer, Neuroprotective, Hepatoprotective, Antimicrobial, Antiviral, and Antiparasitic Agents. Molecules, 30.
41. 41 Coutinho, 2021, Topography of the free energy landscape of Claisen–Schmidt condensation: Solvent and temperature effects on the rate controlling step [DOI]
42. 42 Javahershenas, 2024, Recent advances in microwave-assisted multicomponent synthesis of spiro heterocycles [DOI]
43. 43 Moreno, 2005, Microwaves in organic synthesis. Thermal and non-thermal microwave effects [DOI]
44. 44 Stefanache, A., Marcinschi, A., Marin, G.-A., Mitran, A.-M., Lungu, I.I., Miftode, A.M., Crivoi, F., Lacatusu, D., Baican, M., and Cioanca, O. (2025). Recent advances in green chemistry approaches for pharmaceutical synthesis. Appl. Chem., 5. [DOI]
45. 45 Kappe, 2004, Controlled microwave heating in modern organic synthesis [DOI]
46. 46 Mohamadi, 2013, Regioselective and chemoselective reduction of α,β-unsaturated ketones using NaBH4–Ba(OAc)2 in ethanol–Water
47. 47 Fu, 2020, Chemoselective and metal-free reduction of α,β-unsaturated ketones by in situ produced benzeneselenol from O-(tert-butyl) Se-phenyl seleno carbonate [DOI]
48. 48 Bhowon, M.G., Jhaumeer-Laulloo, S., Li Kam Wah, H., and Ramasami, P. (2014). NaBH4-mediated non-chemoselective reduction of α,β-unsaturated ketones of chalcones in the synthesis of flavans. Chemistry: The Key to Our Sustainable Future, Springer. Chapter 16.
49. 49 Dong, 2023, Efficient Pd on carbon catalyst for ammonium formate dehydrogenation: Effect of surface oxygen functional groups [DOI]
50. 50 Makosza, 2004, Ammonium formate/palladium on carbon: A versatile system for catalytic hydrogen transfer reductions of carbon–carbon double bonds
51. 51 Li, 2008, Selective 1,4-reduction of chalcones with Zn/NH4Cl/C2H5OH/H2O [DOI]
52. 52 Yu, 2023, Transition-metal-free chemoselective reduction of α,β-unsaturated ketones using H2O as a hydrogen source [DOI]
53. 53 Dey, 2024, Chemoselective hydrogenation of α,β-unsaturated ketones catalyzed by a manganese(I) hydride complex [DOI]
54. 54 Datta, 2016, Base-free transfer hydrogenation of nitroarenes catalyzed by micro-mesoporous iron oxide using formic acid as hydrogen source
55. 55 Sevim, 2022, Chemoselective reduction of α,β-unsaturated carbonyl compounds in the presence of CuPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride as a highly efficient catalyst [DOI]
56. 56 Moseley, 2011, A critical assessment of the greenness and energy efficiency of microwave-assisted organic synthesis [DOI]

Cited by 4

Showing 1 of 4 known citations — external sources report more than can currently be individually listed.

Related research

• A Novel Catalytic Synthesis of Flavones under Autoclave Conditions and Comparative Study of Anti-cancer Activity — shares topic coverage
• Thermostability and in-vitro Antibacterial Activity of Aqueous Extracts of Tetrapleura tetraptera Pods on Multidrug Resistant Clinical Isolates — shares topic coverage
• Acute Toxicity, Phytochemistry and Anti-diarrheal Effects of Celtis integrifolia Lam. Aqueous Leaf Extract in Wistar Albino Rats — shares topic coverage
• Understanding the Reactivity of Trimethylsilyldiazoalkanes Participating in [3+2] Cycloaddition Reactions towards Diethylfumarate with a Molecular Electron Density Theory Perspective — shares topic coverage
• Understanding the Origin of the Regioselectivity in Non-Polar [3+2] Cycloaddition Reactions through the Molecular Electron Density Theory — shares topic coverage