Synthesis of Pharmacologically Important Some Novel Pyrimidine and Chalcone Moieties Containing s-triazines
Chemical Science International Journal · pp. 1–7 · Published 12 Jun 2015
10.9734/ACSJ/2015/18654Abstract
s-Triazines containing heterocycles have variety of biological activities including anti-cancer, anti-viral, anti-microbial, anti-inflammatory activities. Various heterocycles have been synthesized by annellation methodology using chalcones as base template. A new series of 2-aminopyrimidine substituted chalcones have been synthesized by the temperature controlled reaction of s-triazines. 4,6-Dichloro-N-(pyrimidine-2-yl)-1,3,5-triazine-2-amine and its various derivatives were synthesized at different temperatures. These were further treated with pyridine-2-aldehydes to furnish corresponding chalcones and the newly synthesized compounds were characterized by IR, 1H-NMR, MS and elemental analysis. s-Traizine containing chalcones have been used as base framework to synthesized five-, six- and seven-membered heterocycles through annellation methodology.
Cited by 2
Gönül Bükülmez, Rahmi Kasımoğulları · Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi · 2026
Hazem A. Ghabbour, Ayman El-Faham · Zeitschrift für Kristallographie - New Crystal Structures · 2016
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