Effects of Aqueous Extract of Ocimum gratissimum on Some Haematological Parameters of Albino Rats
O. A. Ojo, O. I. Oloyede, B. O. Ajiboye, O. I. Olarewaju
Chemical Science International Journal · pp. 74–81 · Published 21 Oct 2013
10.9734/ACSJ/2014/5046Abstract
Aims: To evaluate the effects of aqueous extracts of Ocimum gratissimum leaves on the haematological responses of albino rats. Study Design: Packed cell volume, hemoglobin level, white blood cells and differential cell counts such as neutrophils, lymphocytes, monocytes and eosinophils. Place and Duration of Study: Department of Chemical sciences, (Biochemistry laboratory), Afe Babalola University and Department of Biochemistry, Ekiti State University, Ado Ekiti, Nigeria between February 2013 and march 2013. Methodology: Sixteen albino rats with weight ranging between 100-190g were used. The rats were divided into four groups A, B, C and D; with group D as the control group. Increasing doses (100, 200 and 400mg kg-1 body weight) of the extract were administered orally to the other three treatment group A, B and C for a period of two weeks. Standard chemical procedures were used to analyze for packed cell volume, hemoglobin level, white blood cells and differential cell counts such as neutrophils, lymphocytes, monocytes and eosinophils. Results: The results show a significantly decrease in the hemoglobin level, packed cell volume, white blood cells, neutrophils and lymphocytes respectively. Significant (P = .05) decreases in the level of hemoglobin (Hb) and packed cell volume were observed, whereas no significant (P > .05) differences were observed in percent neutrophils, lymphocyte and monocyte counts of the Ocimum gratissimum treated animals. Conclusion: The result suggests that Ocimum gratissimum leaf extracts administered at the dosages used and for the duration of the experiment suppress the haemopoetic system of albino rats.
References (26)
- 1 Medicinal plants and traditional medicine in Africa
- 2 The medicinal and poisonous plants of southern and eastern Africa.
- 3 Screening of crude extracts of six medicinal plants used in South-West Nigerian unorthodox medicine for anti-methicillin resistant Staphylococcus aureus activity [DOI]
- 4 Anthelmintic activity of essential oil of Ocimum gratissimum Linn. and eugenol against Haemonchus contortus [DOI]
- 5 Phytochemical constituent and antioxidant activity of extract from the leaves of Ocimum gratissimum [DOI]
- 6 Antimicrobial activity of leaf extracts of Ocimum gratissimum on selected diarrhoea causing bacteria in southwestern Nigeria [DOI]
- 7 Ocimum gratissimum L. [DOI]
- 8 Antifungal properties of Ocimum gratissimum essential oil (ethyl cinnamate chemotype) [DOI]
- 9 Antidiarrhoeal effects of Ocimum gratissimum leaf extract in experimental animals [DOI]
- 10 The formulation of an effective topical antibacterial product containing Ocimum gratissimum leaf essential oil [DOI]
- 11 Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice [DOI]
- 12 Inhibition of glutathione S-transferases (GSTs) from parasitic nematodes by extracts from traditional Nigerian medicinal plants [DOI]
- 13 Effect of Essential Oil of Ocimum gratissimum on the Trypanosomatid Herpetomonas samuelpessoai
- 14 Preliminary Clinical Tests on Topical Preparations of Ocimum gratissimum Linn Leaf Essential Oil for the Treatment of Acne Vulgaris [DOI]
- 15 Laboratory Procedures for Veterinary Technicians
- 16 ANTIOXIDANT ACTIVITY OF NIGERIAN DIETARY SPICES
- 17 GLOBAL YIELDS, CHEMICAL COMPOSITIONS AND ANTIOXIDANT ACTIVITIES OF CLOVE BASIL (OCIMUM GRATISSIMUM L.) EXTRACTS OBTAINED BY SUPERCRITICAL FLUID EXTRACTION [DOI]
- 18 The effects of aqueous leaf extract of Ocimum gratissium on haematological and biochemical parameters in rabbits
- 19 Antimutagenic activity of extracts of leaves of four common edible vegetable plants in Nigeria (West Africa) [DOI]
- 20 Essential oil from the leaves and inflorescence of Ocimum gratissimum [DOI]
- 21 CARDIOVASCULAR EFFECTS OF THE ESSENTIAL OIL OF OCIMUM GRATISSIMUM LEAVES IN RATS: ROLE OF THE AUTONOMIC NERVOUS SYSTEM [DOI]
- 22 Beliefs and perceptions of ear, nose and throat-related conditions among residents of a traditional community in Ibadan, Nigeria.
- 23 The Effects of Aqueous Ocimum gratissimum Leaf Extract on Some Biochemical and Hematological Parameters in Male Mice [DOI]
- 24 Antioxidant Activity of the Aqueous Crude Extract of Ocimum gratissimum LINN. Leaf on Basal and Cadmium-induced Serum Levels of Phosphatases in Male Guinea-pigs. [DOI]
- 25 The effects of four agrobotanical extracts and three types of bags on the control of insect pests and moulds of stored yam chips [DOI]
- 26 Indigenous methods used for the management of diarrhoea in an urban community in Edo State, Nigeria [DOI]
Cited by 6
O. Ojo, A. Ojo, B. Ajiboye · 2020
O. Ojo, A. Ojo, B. Oyinloye · BMC Complementary and Alternative Medicine · 2019
Mary A. Okesola, B. Ajiboye, B. Oyinloye · Toxicology Mechanisms and Methods · 2019
A. Adeyi, G. O. Akozi, M. Adeleke · 2015
Kalu Emmanue Okechukwu, A. Jane, N. Joel · 2019
3. Aleshinloye · 2017
Related research
- Evaluation of Hematological Parameter, Glycemic Status and Risk Factors Responsible for Neonatal Septicemia and Bacterial agents Causing Neonatal Sepsis in Chittagong, Bangladesh — shares topic coverage
- Haematological Alterations among Cement Loaders in Port Harcourt, Nigeria — shares topic coverage
- Effects of Energy Drink on Sperm Morphology, Haematological Parametres and Behaviour of Adult Male Mice — shares topic coverage
- Lipid Profile, Cortisol and Haematological Alterations in Simulated Microgravity Using the Bat Model — shares topic coverage
- Impacts of Crude Oil on Reproductive Indices of Residents of Oil Producing Area; a Case Study of Olomoro — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
6
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.