Leukemia Therapy: Mechanisms of Drug Resistance and Investigational Strategies
Ami K. Patel, Mei Zhang, Xudong Huang
Journal of Advances in Medicine and Medical Research · pp. 4134–4153 · Published 29 May 2014
10.9734/BJMMR/2014/10235Abstract
Certain types of leukemia are amongst the first neoplasias to be “cured” with relatively high 5-year remission rates. This is largely due to targeted therapeutics. However, considerable resistance to tumor-specific targeting drugs has developed due to the presence of abundant cancer stem cells, profound genetic diversity, redundant growth/survival pathways and residual disease. Although these issues propose a challenge, they also provide the opportunity for novel innovations of therapy which currently include the development of multi-target kinase inhibitors, multiple drugs acting on multiple targets, key upstream targets covering multiple downstream targets and the future direction of hybrid molecules targeting two or more targets in different pathways.
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