Lipidomic Profiling Disturbance as Good Follow up Index in Obese Diabetic Patients

Abstract

Background: Metabolite profiling, or metabolomics, has become a powerful approach that has been widely adopted for clinical diagnostics. This study aimed to evaluate the metabolomics profile in obese and obese diabetic patients as the early predictor of diabetes with obese patients. Subjects and Methods: This study was conducted on fifty-four from one hundred and sixty unrelated individuals. Participants were mainly 35–70 years of age were classified to four groups are normal, obese and obese diabetic, obese. Results: It was found a significant increase in mean values of LDL concentration in obese as compared to healthy group. It also found that, in obese subjects with the metabolic syndrome and T2D, oxidative stress is increased and the redox state is a potentially useful therapy. Some lipid metabolism-related metabolites, including saturated fatty acides, palmitate and stearate and unsaturated fatty acid archidonic acid, have been identified in diabetic, which indicate a dysregulation of lipid metabolites in diabetic subjects. Conclusion: In conclusion, metabolomics of lipid intermediate was considered as good index of metabolic syndrome and diabetes and can be taken in consideration for follow up and treatment.