Lung Delivery Systems to Optimize Pharmacotherapy of COVID-19: A Concise Review
Mohsen Geza. Alrashedi, Ahmed Geza. Alrashedi, Ahmed Shaker. Ali, Ibrahim M. Ibrahim
Journal of Pharmaceutical Research International · pp. 268–277 · Published 11 Sep 2021
10.9734/jpri/2021/v33i43B32552Abstract
Background: COVID-19 is an ongoing viral pandemic caused by the SARS-COV-2 virus. Several drugs were repurposed for its management; however, most of these drugs were not ideal treatments by traditional methods of administration, whether given by injection or orally. This is due to many reasons including pharmacokinetic limitations or drug-induced adverse effects. There is an urgent need to develop these drugs to target the virus in the lung tissue through inhalation. Objective: To address the gap in knowledge regarding efficacy and safety of pulmonary drug delivery of repurposed antiviral against COVID-19. Findings: Ongoing trials for inhalable formulations of several drugs such as Niclosamide; Remdesivir, Hydroxychloroquine, and Azithromycin among others showed promising results. Conclusion: The development of pharmaceutical forms for inhaled administration of antiviral and anti-inflammatory drugs is an important direction that needs more attention to achieve the optimal management of respiratory infectious diseases.
Cited by 3
Mohsen G. Alrashedi, Ahmed Shaker Ali, Osama Abdelhakim Ahmed · Molecules · 2022
Sagar R. Pardeshi, Eknath B. Kole, Harshad S. Kapare · Pharmaceutics · 2022
Ahmed Shaker Ali, Mohsen Geza Alrashedi, Osama Abdelhakim Aly Ahmed · Polymers · 2022
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