FTIR and UV-Visible Spectrophotometric Derivatization Studies of Artemether
Jane I. Ugochukwu, Eze E. Ajaegbu, Chidinma R. Chukwunwejim, Ikemefuna C. Uzochukwu
Advances in Research · pp. 25–31 · Published 24 Sep 2020
10.9734/air/2020/v21i1030248Abstract
This study was aimed at confirmation of the purity and identity of the artemether and development of an ultraviolet spectrophotometric method for the assaying of artemether utilizing p-nitroaniline as a derivatizing agent. Melting point and Fourier transform infrared spectrophotometer (FTIR) methods were used to confirm the purity and identity of the artemether used in the study. The derivatization process was carried out between 100 µg/ml of the artemether and 500 µg/ml of p-nitroaniline in different molarities (0.5, 1, 2, 3, 4, 5M) of HCl at 60ºC for 45 mins. The melting point ranged between 86-89ºC and the FTIR determination revealed a band at 3169.978 cm-1 due to O-H stretching vibration and C-H stretching at 2996.039 cm-1. There was no observed difference in wavelength between the p-nitroaniline spectrum and the spectra of the derivatized products in different molarities of HCl. p-nitroaniline may not be a proper derivatization reagent for the assay of artemether in pure or dosage form.
Cited by 0
No indexed citations yet.
Related research
- In-Process Quality Checks and Post-Market Surveillance of Artemether-Lumefantrine Fixed-dose Combination Tablets and Suspensions: Current Procedures, Successes, Advances, and Challenges — shares topic coverage
- Immunomodulating Potential of Ekebergia capensis in Murine Schistosoma mansoni Juvenile and Adult Infection — shares topic coverage
- Assessment of Hygienic Effects of Laundering Using Spectrophotometry — shares topic coverage
- Spectrophotometric and Conductometric Study of Methyl Orange - Cetylpyridinium Chloride Ion Pair in Aqueous Solution — shares topic coverage
- Quantification of Total Flavonoids and Phenolic Acids from Microwave Irradiated and Non-irradiated Plants — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.