Serum Antioxidant Enzymes, Haematological Values and Uric Acid Concentrations in Prostatic Disease Patients: An Investigative Study

Abstract

Aim: In this study, the haematology, serum antioxidant enzymes, and uric acid concentrations in prostatic disease patients attending the Nephrology Department of Abia State University Teaching Hospital, Aba were evaluated. Methodology: A total of one hundred and ten (110) adult males (aged 40-80 years) comprising of sixty (60) prostatic disease patients and 50 normal subjects were recruited. The prostatic disease patients comprised of 30 prostatitis, 20 Benign Prostatic Hyperplasia (BPH), and 10 prostate cancer patients. Haematological parameters, antioxidant enzyme levels, and uric acid concentration were determined on blood samples collected from the subjects between January 2017 and December 2019. Results: Results obtained following analysis indicated a significant fall in red blood cell count, haematocrit levels and haemoglobin concentrations in all the prostatic disease patients when compared with control subjects (p<0.05) but no significant difference was observed between the values of these parameters in the three categories of patients studied (p>0.05). Leukocyte and lymphocyte counts in the patients also did not significantly differ from those of the control subjects (p>0.05) but platelets counts were significantly lower (p<0.05). Significant elevations were observed in monocytes and granulocytes counts of prostatitis and prostate cancer patients (p<0.05). Serum antioxidant enzymes activities including superoxide dismutase (SOD) and glutathione peroxidase (GPx) were lower in the prostatic disease patients than in the control (p<0.05) with SOD and GPx levels being lowest in prostatitis and prostate cancer patients respectively while serum uric acid concentration was only higher than control in the prostatitis patients (p<0.05). Conclusion: We, therefore, conclude that complications and deaths due to prostatic diseases may be due to the systemic effects of anaemia and fall in the body’s antioxidant defense line accompanying the conditions.