Spectrophotometric Study of Oxidation Kinetics and Mechanism of Losartan Potassium Using  N-chlorosuccinimide

S. Malini; Kalyan Raj; N. Nanda; J. P. Shubha

doi:10.9734/IRJPAC/2015/18332

Research Article Open access CC BY 4.0

Spectrophotometric Study of Oxidation Kinetics and Mechanism of Losartan Potassium Using N-chlorosuccinimide

S. Malini, Kalyan Raj, N. Nanda, J. P. Shubha

International Research Journal of Pure and Applied Chemistry · pp. 1–16 · Published 2 Jul 2015

10.9734/IRJPAC/2015/18332

Abstract

The kinetics of oxidation of Losartan Potassium [LP] by N-Chlorosuccinimide [NCS] in HCl medium is studied spectrophotometrically at 205 nm at 298 K. The reaction rate shows fractional order dependence on [LP], [HCl] and first order dependence on [NCS]. The reaction rate also shows an inverse fractional order in [Cl-]. Addition of reduction product did not have any significant effect on reaction rate. However, an increase in ionic strength decreases and increase in solvent polarity increases the reaction rate. The activation parameters for the reaction are evaluated. The proposed general mechanism and derived rate law are consistent with observations.

Kinetics oxidation N-chlorosuccinimide spectrophotometric losartan potassium

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S. Malini, Kalyan Raj, N. Nanda, J. P. Shubha (2015). Spectrophotometric Study of Oxidation Kinetics and Mechanism of Losartan Potassium Using N-chlorosuccinimide. International Research Journal of Pure and Applied Chemistry , 1–16. https://doi.org/10.9734/IRJPAC/2015/18332

Affiliations

S. Malini — Department of Chemistry, Dayananda Sagar College of Engineering, Bangalore-560 078, India
Kalyan Raj — Department of Chemistry, BMS College of Engineering, Basavanagudi, Bangalore-560 004, India
N. Nanda — Department of Chemistry, BMS College for Women, Basavanagudi, Bangalore-560 004, India
J. P. Shubha — Department of Chemistry, Don Bosco Institute of Technology, Kumbalgodu, Bangalore-560060, India

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