Biological Evaluation and Spectral Studies of Asymmetrical 3,5-Disubstituted-1,2,4-Oxadiazoles
Yogesh S. Patel, Paresh N. Patel, Hasmukh S. Patel
International Research Journal of Pure and Applied Chemistry · pp. 315–326 · Published 13 Feb 2014
10.9734/IRJPAC/2014/5955Abstract
In present communication, we report the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles derivatives from amino acid derivative with excellent 80-95% yields via a fast and easy procedure under mild conditions. Structures of all the newly synthesized compounds were elucidated based on their elemental analyses and various spectroscopic methods. The in vitro activities of these compounds against bacteria and fungi were evaluated by the well diffusion and the minimum inhibitory concentration (MIC) methods. Some of the synthesized derivatives were found active as compare to standard drugs.
Cited by 2
Abd El‐Badih A. G. Ghattas, Ahmed Khodairy, Hassan M. Moustafa · Journal of Heterocyclic Chemistry · 2016
Bahgat R. M. Hussein, Ali M. Ali · Journal of Heterocyclic Chemistry · 2019
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