Evaluation of Histopathological Diagnosis and Determination of Grades and Stages in Breast Cancer

Abstract

Background: Breast cancer is the most frequent neoplasm in women. According to American Cancer Society in 2019, an estimated 268,600 new cases of invasive breast cancer was diagnosed among women in USA. In Bangladesh, breast cancer has rapidly become the number one cancer in female pushing cervical cancer to second position. Objective: To evaluate histopathological diagnosis and determination of grades and stages in breast cancer. Methods: This cross-sectional descriptive type of study was conducted in the Department of Pathology, Rajshahi Medical College. Forty-five untreated cases of breast cancer were included in this study between the period of July 2019 to June 2021 and paraffin embedded sections were obtained from representative mastectomy specimen. The sections were stained with hematoxylin and eosin stain followed by evaluation of angiogenesis by using CD34 antibody. Results: According to histopathological grade 51.1% belonged to grade III followed by 28.9% grade II and 20% grade I. Histological stage showed most of the cases was stage II (48.9 %) followed by stage I (26.7 %) then stage III (24.4 %). Upon statistical analysis, a significant relation was obtained between MVD with increasing histologic grades and stages.  Conclusion: In conclusion we can say that histological stage showed most of the cases was stage II followed by stage I then stage III.