Multiple-Antibiotic Resistance in Salmonella enterica Serovars Isolated in Iran Harboring Class 1 Integrons
Bahareh Rajaei, Nahid Sepehri Rad, Farzad Badmasti, Mohamad Reza Razavi, Mohammad Reza Aghasadeghi, Raheleh Saboohi, Taraneh Rajaei, Arfa Moshiri, Seyed Davar Siadat
Microbiology Research Journal International · pp. 186–193 · Published 8 Oct 2014
10.9734/BMRJ/2015/9303Abstract
Aims: This research was carried out to detect the content and distribution of class 1 integrons in multidrug resistant Salmonella isolates. Materials and Methods: Eighty four clinical isolates of Salmonella serovars were subjected to molecular detection of class 1 integrons following the antimicrobial susceptibility test using disk diffusion method and MIC determination. Results: Eleven isolates (13.1%) which were resistant to at least 4 groups of antimicrobial agents considered as MDR (multidrug resistant) Salmonella serovars. The intI1 gene and internal variable regions (IVRs) of class 1 integron were detected in 50 (59.5%) and 35 (70%) of Salmonella clinical isolates respectively. Analysis of the sequence data revealed four gene cassette arrays including the dhfr7 (0.8 kb), aadA1 (1kb), blaP1 (1.2 kb), dhfr1-aadA1 (1.6 kb) with eight IVR distribution patterns. Conclusion: Detection of class 1 integron carrying gene cassettes which confer resistance to different classes of antibiotics such as aminoglycosides, ß-lactams and trimethoprim confirms that integron-mediated antimicrobial gene cassettes are prevalent in Salmonella serovars isolated in Iran.
References (20)
- 1 Aminoglycoside modifying enzymes [DOI]
- 2 Integrons: agents of bacterial evolution [DOI]
- 3 The changing epidemiology of resistance [DOI]
- 4 Incidence of Class 1 and 2 Integrases in Clinical and Commensal Bacteria from Livestock, Companion Animals, and Exotics [DOI]
- 5 Importance of integrons in the diffusion of resistance [DOI]
- 6 Occurrence of integron-associated resistance gene cassettes located on antibiotic resistance plasmids isolated from a wastewater treatment plant [DOI]
- 7 Towards more virulent and antibiotic-resistantSalmonella? [DOI]
- 8 Salmonella Virulence Plasmid: Modular Acquisition of the spv Virulence Region by an F-Plasmid in Salmonella enterica Subspecies I and Insertion Into the Chromosome of Subspecies II, IIIa, IV and VII Isolates [DOI]
- 9 Association of virulence plasmid and antibiotic resistance determinants with chromosomal multilocus genotypes in Mexican Salmonella enterica serovar Typhimurium strains [DOI]
- 10 Antibiotic resistance, integrons and Salmonella genomic island 1 among non-typhoidal Salmonella serovars in The Netherlands [DOI]
- 11 Genetic basis of multidrug resistance in Salmonella enterica serovars Enteritidis and Typhimurium isolated from diarrheic calves in Egypt [DOI]
- 12 Class 1 integrons and resistance gene cassettes among multidrug resistant Salmonella serovars isolated from slaughter animals and foods of animal origin in Ethiopia [DOI]
- 13 Characterization of antibiotic resistance genes linked to class 1 and 2 integrons in strains of Salmonella spp. isolated from swine [DOI]
- 14 Surveillance of antibiotic resistance evolution and detection of class 1 and 2 integrons in human isolates of multi-resistant Salmonella Typhimurium obtained in Uruguay between 1976 and 2000 [DOI]
- 15 Molecular characterisation of class 1 integrons in Salmonella enterica serovar Choleraesuis isolates from southern Taiwan [DOI]
- 16 Class 1 integrons in multidrug-resistant non-typhoidal Salmonella enterica isolated in Spain between 2002 and 2004 [DOI]
- 17 In vivo transfer of an incFIB plasmid harbouring a class 1 integron with gene cassettes dfrA1-aadA1 [DOI]
- 18 Distinctive human and swine strains of Salmonella enterica serotype Wien carry large self-transferable R-plasmids. A plasmid contains a class 1-qacEΔ1–sul1 integron with the dfrA1–aadA1a cassette configuration [DOI]
- 19 Intracellular Steady-State Concentration of Integron Recombination Products Varies with Integrase Level and Growth Phase [DOI]
- 20 Molecular Detection of Antimicrobial Resistance Gene Cassettes Associated with Class 2 Integron in Salmonella Serovars Isolated in Iran [DOI]
Cited by 4
Shuvasree Bej, Surendra Swain, A. Bishoyi · Water, Air and Soil Pollution · 2023
F. Firoozeh, Zeinab Mahluji, A. Khorshidi · Antimicrobial Resistance and Infection Control · 2019
Showing 2 of 4 known citations — external sources report more than can currently be individually listed.
Related research
- Efficacy of Nitrofurantoin and Fosfomycin against Extended Spectrum Beta Lactamase Producing Uropathogens in the Era of Antibiotic Resistance: A Cross-sectional Study — shares topic coverage
- Multidrug-resistant Uropathogens in Urinary Tract Infection Patients: A Comprehensive Study at Al-Rifai Teaching Hospital — shares topic coverage
- Potential of Surface Water Gram-negative Bacterial Flora as a Reservoir of Heterogeneous Plasmid and Multi-drug Resistance Phenomenon — shares topic coverage
- Poultry Environment as a Reservoir of Antimicrobial Resistant Bacteria – A Nigerian Story — shares topic coverage
- Bacteriological Quality and Prevalence of Multidrug Resistant Gram-negative Bacteria from Surface and Underground Domestic Water Sources in Selected Locations in Ibadan, Oyo State, Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
20
Page views
0
PDF downloads
13
Outbound clicks
4
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.