Neurobehavioral and Micro Structural Evaluation of the Anti-anxiety Potential of Flaxseed oil Following Rotenone-induced Parkinson’ Disease in Mice
Philemon Dauda Shallie, Bamidele Richard Babatunde, Olugbenga Olawole Olayinka, Damilola Joseph Talabi, Helen Bassey Akpan, Royhaan O. Folarin, Oluwole Ojo Alese, Oluwadamilola Faith Shallie
International Neuropsychiatric Disease Journal · pp. 1–12 · Published 25 Jul 2017
10.9734/INDJ/2017/34206Abstract
Aim: This study investigated the neurobehavioral and micro structural anti-anxiety potential of flaxseed oil following rotenone-induced Parkinson’ disease [PD] in mice Study Design: Fifty-six adult male and female mice (Mus musculus) weighing between 23.9-26.3 grams were used for this study. The mice were randomly placed into four groups of fourteen mice each: A (Control; mice pellets), B (Rotenone 3 mg/kg, IP), C (Rotenone + Flaxseed oil 0.3 ml orally), and D (0.3 ml Flaxseed + Rotenone). Place and Duration of the Study: Department of Anatomy, Olabisi Onabanjo University. Between May and September, 2016. Methodology: The brains were excised, weighed and appropriate sections taken and processed histology and labelled with H&E, silver and Nissl stains and immuno-cytochemically with GFAP. Results: The results showed significant (P<0.005) increase in anxiety related activities and neuronal structural derangement, and degeneration of astrocytes in the rotenone-induced Parkinson’s mice, which were counter/ameliorated by flaxseed oil treatments. Conclusion: In conclusion, flaxseed oil acts as a neuro-protective agent against the insult of rotenone model of Parkinson’s disease, thus it should be further evaluated as a potential therapeutic candidate in the management/treatment of Parkinson's disease.
Cited by 2
Dilara Nemutlu Samur, Güven Akçay, Sendegül Yıldırım · Neuropharmacology · 2022
Fatemeh Noroozi, Dept. of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran, Masoumeh Asle-Rousta · Journal of Advances in Medical and Biomedical Research · 2022
Related research
- Perceived Stress and Anxiety in Women during Labour: A Case of Tamale West Hospital, Tamale, Ghana — shares topic coverage
- Anxiety and Visual Field Assessment Reliability in Glaucoma Patients — shares topic coverage
- Effect of Crude Ethanol Leaf-extract of Murraya koenigii on Anxiety in Mice — shares topic coverage
- Antiretroviral Therapy may have Anxiogenic Effect on Subjects — shares topic coverage
- The Prevalence of Irritable Bowel Syndrome (IBS) in a Private-University in Malaysia, and Its Associated Factors Including Stress, Depression and Anxiety — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
2
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.