New Insight in the Sedative and Anxiolytic Activities of Amaranthus tricolor L. Leaves Extract in Mice
Nusrat Jahan, Md. Rabiul Hossain, Muhammad Kamal Hossain, Md. Rashadul Alam, Shimul Das
Asian Food Science Journal · pp. 16–24 · Published 31 Dec 2020
10.9734/afsj/2020/v19i430245Abstract
Aims: The present study was planned to assess the sedative and anxiolytic efficacy of Amaranthaus tricolor L methanolic extract in vivo. Place and Duration of Study: Department of Pharmacy, between January 2018 and August 2018. Methodology: In this experiment, the crude extract of Amaranthus tricolor L. was evaluated for its CNS depressant effect using rodent behavioral models, such as open field, hole cross and rota rod tests for its sedative properties and an elevated plus maze test for its anxiolytic potential, respectively. Results: In sedative assay, a dose-dependent and statistically significant (p<0.05) suppression of locomotors activity of the mice in both open field and hole cross test was exhibited by theextract at a dose of 200 and 400 mg/kg body weight. The extract also displayed increased percentage of entry into open arms at both doses in anxiolytic potential study. At a dose of 400 mg/kg body weight significant anxiolytic activity (p<0.05) was found compared to the standard diazepam. Conclusion: The pivotal CNS depressant and anxiolytic activity of the methanolic extract of Amaranthus tricolor L leaves was discovered in this experiment. Further research on the extract's biologically active phytochemicals may provide access to therapeutic intervention.
References (16)
- 1 The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review [DOI]
- 2 The Traditional Medicine and Modern Medicine from Natural Products [DOI]
- 3 A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8. [DOI]
- 4 Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding. [DOI]
- 5 Side effects of treatment with benzodiazepines.
- 6 Refinement and Evaluation of a Pharmacophore Model for Flavone Derivatives Binding to the Benzodiazepine Site of the GABAA Receptor [DOI]
- 7 Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety [DOI]
- 8 Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model [DOI]
- 9 Anxiolytic activity of methanol leaf extract of Achyranthes aspera Linn in mice using experimental models of anxiety [DOI]
- 10 Betalains from Amaranthus tricolor L.
- 11 Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice [DOI]
- 12 Neuropharmacological effect of the aqueous extract of Sphaeranthus senegalensis in mice [DOI]
- 13 Evaluation of Anti-anxiety Activity of Justicia gendarussa Burm [DOI]
- 14 Health Services Research In A Market-Oriented Health Care System [DOI]
- 15 In vivo Sedative and Anxiolytic Potential in Mice for Methanolic Extract of Tinospora cordifolia [DOI]
- 16 ANTIDEPRESSANT AND ANXIOLYTIC EFFECTS OF ALCOHOLIC EXTRACT FROM TEPHROSIA PUMILA (L.) PERS [DOI]
Cited by 1
Oliver Villaflores, R. Vasquez, Yutaka Kuroki · Next Research · 2026
Related research
- Promoting Color Brightness of Clown Loach (Chromobotia macracanthus Bleeker) by Mixing Red Spinach (Amaranthus tricolor L.) Powder with Feed Stuff — shares topic coverage
- Evaluation of In-vivo Neuropharmacological Effect of Sarcochlamys pulcherrima Leaf Extract in Animal Model — shares topic coverage
- Anxiolytic Effect of Aqueous Root Extract of Citrus aurantium in Wistar Albino Rats — shares topic coverage
- Preventive Effects of Ocimum gratissimum (Lamiaceae) Leaf Decoction on Pilocarpine-induced Seizure and Anxiety in White Mice (Mus musculus Swiss) — shares topic coverage
- Evaluation of the Anxiolytic Effect of Methanolic Leaves Extract of Paullinia pinnata Lin in Mice — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
1
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.