Matrix-assisted Laser Desorption/Ionization Mass Spectra Study of Complexed Alkaloid from Colchicum Species

Abstract

Complexes are biologically useful compounds and they have many biological activities. Colchicine can form stable complexes with alkali metals. Till now colchicine complexes have not been characterised by modern mass spectra methods such as MALDI MS (Matrix-assisted laser desorption/ionization mass spectral). The aim of this study was to check fragmentation pathways of colchicine complexes with alkali metals: Li+, Na+, K+ by MALDI MS mass spectra. The colchicine complexes with Li+, Na+, K+ cations of perchlorates and iodides have been synthesised and studied in details by MALDI MS mass spectra.