Comparison of Preoperative Subconjunctival Injection of Mitomycin C versus Conjunctival Auto Graft with Fibrin Glue in the Management of Primary Pterygium - A Clinical Study

Abstract

Aim: To evaluate the outcome of preoperative subconjunctival Mitomycin C to conjunctival auto grafting using fibrin glue with respect to the recurrence rate and complications. Methodology:  A prospective randomized hospital based study was conducted. 60 eyes were taken into consideration with primary progressive pterygium and were randomly divided into 2 groups of 30 each. In group A subconjunctival injection of Mitomycin C (MMC) 0.1 ml of 0.1 mg/ml was given 1 month before bare sclera technique and in group B pterygium excision with conjunctival auto graft using fibrin glue was performed. They were regularly followed up for 18 months. Results: The mean age of the patients in this study was a 39.6±12.3 year with females outnumbering the males. The mean follow up period of group A was 10.6 ±5.44 months while in group B it was 11.2 ±4.49 months. It was found out that the recurrence rate with subconjunctival MMC before bare sclera technique was 3.4 %while the recurrence rate with conjunctival autograft using fibrin glue was6.7%. The average surgery time was more in group B than compared to Group A. Both the techniques were not associated with any vision threatening complications. Conclusion: Administration of subconjunctival injection of MMC 1 month before the bare sclera technique is considered to be safer, economical, less time consuming, technically less demanding and as effective as conjunctival autograft with fibrin glue.