Revised Formal Total Synthesis of Dehydro-δ-Viniferin and Anigopreissin A
Alessandro Santarsiere, Marianna Volgare, Lucia Chiummiento
Organics · pp. 17–17 · Published 16 Apr 2026
10.3390/org7020017Abstract
This work presents a revised total synthesis of two pharmacologically relevant benzofurans using newly developed environmentally friendly methodologies. In particular, we focused on establishing improved synthetic routes to stilbene dimers under milder and more sustainable reaction conditions. During our investigations, we optimized an efficient Sonogashira coupling carried out in water, which, followed by a Suzuki-like reaction conducted in dimethyl carbonate (DMC) in the absence of any transition metals, served as the key step for the synthesis of the benzofuran core.
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