Synthesis and Morphology of Biological Active Compounds

Abstract

Aim: The objectives of this study were to investigate the effect of crystallization 5-H-dibenz(b,f)azepin-5-carboxamide and fexofenadine hydrochloride from different solvents commonly used for purification of drugs during their final stages of synthesis. The synthetic pathway has presented the number of reactions in which the starting material is converted to the desired molecule structure. 5-H-dibenz(b,f)azepin-5-carboxamide is pharmaceutically active compound which is used in the treatment of epilepsy and trigeminal neuralgia. The synthesis 5-H-dibenz(b,f)azepin-5-carboxamide is performed in accordance with the mechanism of the nucleophylic substitution. When substances crystallize in a different but chemically identical crystal forms, then we talk about polymorphism. 5-H-dibenz(b,f)azepin-5-carboxamide is a very important pharmaceutically active compound which is present in at least four anhydrous polymorphic modifications, two of which are monoclinic, one is trigonal and the final one is triclinic. Fexofenadine hydrochloride, a piperidine derivative is H1 antihistaminic active compound. A number of polymorph modifications is present in the structure of molecule. Reaction of esterification, Friedel-Craft’s alkylation, condensation, oxidation and reduction are included in the Fexofenadine hydrochloride synthesis pathway.