Synthesis and Theoretical Evaluation of New Binuclear Cr(III), Co(II) and Fe(III) Metal Complexes of Tetradentate Schiff Base and Its Biological Activity

Abstract

The new acyclic Schiff base [L] ligand: 3,3'-(1E,1'E)-1,1'-(2,2'-azanediylbis (ethane-2,1-diyl)bis(azan-1-yl-1-ylidene))bis(ethan-1-yl-1-ylidene) bis(4-hydroxy-6-methyl-2H-pyran-2-one) derived from condensation of one mole diethylene diamine triamine (dien) with two moles of dehydroacetic acid have behaved tetra dentate dibasic chelating agent with all metal ions under study. Three bimetallic Cr(III), Co(II) and Fe(III) acyclic polydentate complexes [M2L2Cl2]Cl4 ,M=Cr(III) , Fe(III)  and [M2L2Cl2], M=Co(II) have been prepared and fully characterized by UV-Vis., FTIR, micro-elemental  analysis , as well as the magnetic  moments  of  solid complexes  and   the measurements  of  molar conductance in DMSO solution helped  us in investigate the chemical  structure of  bimetallic models . From the results obtained by different techniques, it was found that the proposed structures of the prepared complexes have octahedral structure. A theoretical treatment of the formation of complexes in the gas phase was studied, this was done using the HYPERCHEM-6 program in general. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands.